中药凝胶贴膏与软膏剂的体外透皮特性比较研究  

Comparative study on the transdermal characteristics of Chinese herbal gel paste and ointment

作　　者：冯乾坤[1] 商学君 侯爽 王沛[1] 

机构地区：[1]长春中医药大学药学院,吉林长春130117 [2]吉林工商学院外国语学院

出　　处：《中国卫生工程学》2017年第6期732-733,共2页Chinese Journal of Public Health Engineering

基　　金：吉林省科技厅科技支撑项目(20120446)

摘　　要：目的研究主药成分及处方量相同的两种不同剂型的中药烫伤制剂透皮吸收效果。方法采用改进的Franz扩散池进行体外透皮试验,取离体大鼠鼠皮作为透皮屏障,采用紫外分光光度法测定接收液中的有效成分含量并作为评价指标,比较两种剂型的透皮吸收能力。结果同一时间段内,凝胶贴膏的累积透皮量和累积透皮率均明显高于软膏剂,而且随着时间的增加,二者差值逐渐增大,尤其在12 h时,凝胶贴膏的累积透皮率约为软膏剂的1.6倍。结论凝胶贴膏在透皮性能上明显优于软膏剂,其透皮吸收迅速、载药量大、使用更方便,可在临床上进一步研究使其用于治疗烧烫伤。Objective To compare the transdermal absorption effect of two kinds of Chinese herbal medicine preparations with the same amount of the main components and the prescription.Methods Using the improved Franz transdermal test of diffusion cell and isolated rat skin as transdermal barrier,spectrophotometric determination of effective components in receiving liquid and as the evaluation index by UV,two type transdermal absorption ability were compared. Results At the same time,the cumulative transdermal plaster gel and cumulative permeation rate were significantly higher than that of the ointment,but as time increases,the difference between the two is gradually increased,especially in the 12 h,the accumulation of gel plaster skin penetration rate was about 1.6 times more than the ointment.Conclusion Gel in transdermal plaster is obviously superior to that of the ointment,the transdermal absorption of fast,large loading capacity and more convenient to use,can be in further clinical research for the treatment of burn.

关 键 词：透皮试验 累积透皮量 累积透皮率 

分 类 号：R283[医药卫生—中药学]