四氢小檗碱药理作用研究进展  

Research progress on pharmacological effects of tetrahydroberberine

作　　者：季宇彬[1] 刘欣 于蕾[1] 窦利民[1,2] 张小坡 

机构地区：[1]哈尔滨商业大学生命科学与环境科学研究中心,黑龙江哈尔滨150076 [2]海南医学院药学院,海南海口571199

出　　处：《中草药》2017年第24期5270-5275,共6页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81760628;81560696)

摘　　要：四氢小檗碱(THB)属于四氢异喹啉类生物碱,来源于罂粟科植物延胡索的块根,也可由小檗碱氢化合成。与小檗碱比较,THB同样具有多种显著的生物活性。目前研究发现THB具有抗高血压、抗心律失常、抗纤维性颤动、抗急性心肌梗死及对缺血再灌注损伤的治疗及保护作用。也有报道称THB具有抗氧化、调节胃肠功能等作用。通过检索Pubmed、CNKI等数据库,查阅国内外相关文献,旨在对THB的药理作用进行归纳总结,为THB的深入研究提供参考。Tetrahydroberberine（THB） belongs to the alkaloid of tetrahydroisoquinoline, which is derived from the roots of Corydalis yanhusuo and can also be hydrogenated from berberine. THB has a variety of significant biological activities compared to berberine. It is reported that THB has the effects of anti-hypertension, anti-arrhythmia, anti-fibrillation and against acute myocardial infarction, and also can treat and protect the injury of ischemic and reperfusion. Moreover, other research has found its effects upon anti-oxidant and regulating the functions of gastrointestinal tract. By searching literature of domestic and foreign from Pubmed, CNKI and other databases, pharmacological activities of THB were summarized in this paper, in order to provide reference for the further study of THB.

关 键 词：四氢小檗碱 抗高血压 抗心律失常 抗纤维性颤动 抗急性心肌梗死 缺血再灌注损伤 抗氧化 调节胃肠功能 

分 类 号：R285[医药卫生—中药学]