血清基质金属蛋白酶-2在脑白质病变患者头颅MRI各分级中的表达水平  

The expression level of serum matrix metalloproteinase-2 in the grades of brain MRI in patients with white matter lesions

作　　者：闫少净 朴翔宇[1] 赵洁[1] 梁倩[1] 

机构地区：[1]大连大学附属中山医院神经内一科,116000

出　　处：《临床神经病学杂志》2017年第6期435-438,共4页Journal of Clinical Neurology

摘　　要：目的探讨血清基质金属蛋白酶-2(MMP-2)在脑白质病变(WML)患者头颅MRI各分级中的表达水平。方法选取WML患者60例为病例组和无WML患者30例为对照组。收集临床资料,并检测血清MMP-2水平。结果血清MMP-2水平在对照组分别与WMLⅠ级、WMLⅡ级、WMLⅢ级之间比较差异均有统计学意义(均P<0.001);血清MMP-2水平在WMLⅠ级分别与WMLⅡ级、WMLⅢ级之间比较差异均有统计学意义(均P<0.001),血清MMP-2水平在WMLⅡ级与WMLⅢ级之间比较无统计学差异(P>0.05)。经有序Logistic回归分析,结果显示年龄(OR=2.144,95%CI:1.248~3.684,P=0.006)、血浆同型半胱氨酸(Hcy)水平(OR=4.432,95%CI:1.344~14.600,P=0.014)、MMP-2(OR=7.622,95%CI:4.063~14.296,P=0.001)与WML严重程度相关。结论 MMP-2可能是WML发病机制中的关键因素之一,血清MMP-2水平与WML严重程度具有相关性。Objective To investigate the expression level of serum matrix metalloproteinase-2（ MMP-2） in the grades of brain MRI in patients with white matter lesions（ WML）. Methods Sixty patients with WML were selected as patients group and 30 patients without WML as the control group. Clinical data were collected and serum MMP-2 levels were measured. Results The differences of serum MMP-2 levels between normal group and WML grade Ⅰsubgroup,WML gradeⅡsubgroup,WML gradeⅢsubgroup were statistically significant respectively（ all P 0. 001）;the differences of serum MMP-2 levels between WML gradeⅠsubgroup and WML gradeⅡsubgroup,WML gradeⅢsubgroup were statistically significant respectively（ all P 0. 001）; the difference of serum MMP-2 levels between WML gradeⅡ subgroup and WML grade Ⅲ subgroup,WML grade Ⅲ subgroup had no statistical significance（ P 0. 05）. Logistic regression analysis showed that age（ OR = 2. 144,95% CI： 1. 248-3. 684,P = 0. 006）,pasma level of homocysteine（ Hcy）（ OR = 4. 432,95% CI： 1. 344-14. 600,P = 0. 014）,level of MMP-2（ OR = 7. 622,95%CI： 4. 063-14. 296,P = 0. 001） was associated with WML severity. Conclusions MMP-2 may play a critical role in the pathogenesis of WML. The level of MMP-2 is associated with the severity of WML.

关 键 词：脑白质病变 基质金属蛋白酶-2 危险因素 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742[医药卫生—诊断学]