基于脉搏色素光密度法的心输出量测量系统  

Cardiac Output Measurement System based on Pulse Dye Densitometry

作　　者：赵银银 王钢[2] 张大可[2] 蔡靖[3] 

机构地区：[1]北华大学工程训练中心,吉林吉林132021 [2]北华大学电气信息工程学院,吉林吉林132021 [3]吉林大学仪器科学与电气工程学院,吉林长春130061

出　　处：《生物医学工程研究》2017年第4期287-290,共4页Journal Of Biomedical Engineering Research

基　　金：国家"十二五"科技支撑计划(2015BAI02B04);吉林省发改委省级产业创新专项资金项目(2016C052-2);吉林省教育厅"十二五"科学技术研究规划重点项目(440020031134);吉林省教育厅科学研究规划项目(JJKH20170034KJ;JJKH20170035KJ)

摘　　要：临床上心输出量(CO)等心血管血流动力学参数是心脏功能状况及心血管疾病的诊断依据,传统CO检测方法操作繁杂、有创伤以及患者术后易引发并发症。针对此问题,研究了一种基于脉搏色素光密度法的心输出量测量系统,以朗伯比尔定律和色素稀释理论为基础,通过选取合适的双波长探测光源(805nm/940 nm)实现了动脉吲哚氰绿(ICG)色素浓度谱的无创实时测量,从ICG浓度稀释曲线中计算出CO的数值。将本系统测量的值与当前测量CO的金标准热稀释法的结果进行对比,平均误差为4.79%,相关系数为0.99。实验结果表明:本研究所设计的心输出量测量系统实现了CO的无创、准确测量,可为临床检测CO提供一种新的选择。Cardiac output （CO） and other cardiovascular hemodynamic parameters were taken as diagnostic basis of heart function condition and cardiovascular disease in clinic. But the traditional detection methods have disadvantages such surgical trauma,as well as possibility of complication for patients. To solve the problem,a cardiac output measurement system basedon pulse dye densitometry （PDD） was researched. With lambert beers la＊w and dye dilution theory as the foundation,the noninvasive and real - time measurement of arterial indocyanine green （ICG） dye concentration spectrum was realized, by choosing appropriate du-al wavelength detection light source （805nm and 940nm） , and CO could be calculated from the concentration pared with the ＂ gold standard＂ method of thermodilution, the average relative error was 4. 79% and the correlation coefficient was 0.99. The result indicates that the CO measurement system implements the noninvasive and accurate measurement and provides a ne＊w choice for clinical detection of CO.

关 键 词：心输出量 脉博色素光密度法 吲哚氰绿 色素稀释理论 热稀释法 

分 类 号：R318[医药卫生—生物医学工程] O657.33[医药卫生—基础医学]