金纳多口服液对进展性正常眼压性青光眼视神经保护作用的临床研究  

Study on the Effect of Ginkgo Biloba Extract on Optic Nerve in Progressive Normal-tension Glaucoma Patients

作　　者：韩红波[1] 刘春姿[1] 

机构地区：[1]浙江中医药大学附属第一医院,杭州310006

出　　处：《浙江中医药大学学报》2017年第12期984-989,共6页Journal of Zhejiang Chinese Medical University

基　　金：浙江省医药卫生科技计划(2014KYA158)~~

摘　　要：[目的]观察金纳多口服液对进展性正常眼压性青光眼(normal-tension glaucoma,NTG)的视神经保护作用。[方法]选择60例(60只眼)已控制在目标眼压的NTG患者,按随机数字表法分为对照组和治疗组,每组30例。对照组行常规治疗,治疗组在常规治疗的基础上口服金纳多口服液2次/d,1m L/次,5个月为1个疗程,连续治疗3个疗程。观察患者最佳矫正视力、眼部血流动力学、视野、视网膜神经纤维层厚度及视盘盘沿面积变化。[结果]两组患者最佳矫正视力治疗前、后无明显影响,比较无统计学意义(P>0.05);治疗后,治疗组血流动力学指标收缩期流速﹙peak systolic velocity,PSV﹚、舒张末期流速﹙end diastolic velocity,EDV﹚较治疗前显著增加,阻力指数﹙resistive index,RI﹚明显降低(P<0.05);而对照组治疗前后差异无统计学意义(P>0.05);治疗后治疗组视野平均缺损(mean visual field defects,MD)下降速度与对照组比较明显变慢(P<0.05);治疗后治疗组视网膜神经纤维层厚度变薄、视盘盘沿面积变窄趋势慢于对照组(P<0.05)。[结论]金纳多口服液能改善眼部血流动力学,延缓青光眼视神经恶化,对NTG患者的视神经有一定的保护作用。[Objective] To evaluate the effect of Ginkgo biloba extract on optic nerve in progressive normal-tension glaucoma patients. [Methods] 60 cases of patients suffered from controlled normal-tension glaucoma were randomly divided into control and treatment groups, 30 cases in each respectively. The patients in the control group received the conventional treatment（eye drops or surgical treatment）, additionally the patients in the treatment group received Ginkgo biloba extract（twice a day,1 ml each time）. 5 months was a therapeutic course, after 3 therapeutic courses the best corrected visual acuity, ocular hemodynamics, visual field, retinal nerve fiber layer thickness and optic disc data were detected and statistically studied. [Results] There was no significant difference in the best corrected visual acuity between control group and treatment group（P〈0.05）. The end diastolic velocity（EDV）, peak systolic velocity（PSV） were increased significantly and resistive index（RI） was decreased significantly in treatment group after treatment（P〈0.05）, while the EDV, PSA, RI in control group before and after treatment were without significant differences（P〈0.05）. The mean visual field defects（MD） in treatment group after treatment were much lower than the control group（P〈0.05）. The reduction trends of the retinal nerve fiber layer thickness and rim area in treatment group after treatment were slower than control group significantly decreased（P〈0.05）. [Conclusion] Ginkgo biloba extract can improve the ocular hemodynamics, delay the deterioration of the best corrected visual acuity and visual field damage, extend the losing time of visual retinal nerve fiber layer thickness and rim area. It has protective effect on optic nerve in normal-tension glaucoma.

关 键 词：金纳多口服液 正常眼内压 青光眼 血流动力学 视野 视网膜神经纤维层厚度 视盘盘沿面积 

分 类 号：R276[医药卫生—中医五官科学]