大面积烧伤患者外周血Th17细胞及相关细胞因子变化  

Changes of Th17 cells and related cytokines in peripheral blood in patients with extensive burn

作　　者：邹俊[1] 张中军[1] 胡娜[1] 毛洪雅 

机构地区：[1]无锡市第三人民医院麻醉科,江苏省214041

出　　处：《江苏医药》2017年第24期1766-1768,共3页Jiangsu Medical Journal

摘　　要：目的探讨大面积烧伤患者外周血Th17细胞及相关细胞因子变化。方法采用流式细胞术和ELISA法分别检测20例烧伤面积≥30%总体表面积患者(A组)和10例健康志愿者(B组)的外周血Th17细胞和IL-17、IL-6浓度。A组采血时间为≤伤后6h(T1)、伤后24h(T2)和7d(T3)。结果 T1和T2时,A组Th17细胞比例和血浆IL-17、IL-6浓度均高于B组(P<0.01);T3时,A组外周血Th17细胞比例和血浆IL-17、IL-6浓度低于T1、T2时和B组(P<0.05)。结论大面积烧伤患者于烧伤后,由T淋巴细胞介导的细胞免疫功能先是增强,而后明显受到抑制,机体免疫功能下降。Objective To investigate the changes of Th17 cells and related cytokines in peripheral blood in the patients with extensive burn.Methods The propotion of Th17 cells and expressions of IL-17 and IL-6 in peripheral blood were detected by flow cytometry and ELISA in 20 patients（group A）with burn area≥30% of total body surface area at 6 hours（T1）,24 hours（T2）and7 days（T3）after burn.Ten healthy volunteers were taken as the controls（group B）.Results The propotion of Th17 cells and plasma expressions of IL-17 and IL-6 at T1 and T2 were higher in group A than those in group B（P〈0.01）,which in group A at T3 were lower than those at T1 and T2 and those in group B（P〈0.05）.Conclusion The cellular immune function mediated by T lymphocytes in the patients with extensive burn is enhanced after burn at first and depressed thereafter with a reduced immune function.

关 键 词：大面积烧伤 TH17细胞 白细胞介素17 白细胞介素6 

分 类 号：R614[医药卫生—麻醉学]