妊娠期人乳头状瘤病毒感染的母婴传播的研究  

Research of mother-to-infant transmission of human papilloma virus infection during pregnancy

作　　者：尹香花 卢丹 蒋敏 经叶花 杨丽娟 

机构地区：[1]江苏省苏北人民医院妇产科,扬州大学临床医学院,江苏扬州225001

出　　处：《实用临床医药杂志》2017年第23期57-59,共3页Journal of Clinical Medicine in Practice

基　　金：江苏省妇幼保健科研项目(F201342)

摘　　要：目的探讨妊娠期人乳头状瘤病毒(HPV)感染的母婴传播途径及对胎婴儿的影响。方法选取生殖道感染HPV的妊娠期女性共175例为研究组,另选取371例同期的未感染HPV的妊娠期女性作为对照组,比较研究组与对照组的妊娠结局、新生儿感染率。结果研究组新生儿HPV的感染率为6.86%(12/175);研究组不同分娩方式(经阴道分娩/剖宫产)的羊水、胎盘、产后初乳、新生儿脐血、咽喉分泌物等的HPV检测率差异无统计学意义;研究组的妊娠结局如自然流产、早产、胎膜早破、胎儿生长受限、新生儿呼吸窘迫综合征等发生率均高于对照组;破膜时间长短与新生儿感染HPV有一定关系。结论 HPV在母婴间的传播不能通过改变分娩方式完全避免,其还可经脐血、血液、羊水和胎盘发生垂直传播及母乳喂养引起水平传播。Objective To investigate the possible routes of mother- to-infant transmission ofhuman papilloma virus （HPV） during pregnancy and its influence on fetuses andA total of 175 HPV-positive pregnant women were selected as study group and 344 pregnant women in the same period were as control group. The pregnant outcomes and neonatal infec-tion rates of two groups were studied. Results The rate of HPV infection in the 86% （12/175 ） . There were no significant difference in HPV detection rate regarding amniotic fluid,placenta,postpartum milk, neonatal umbilical cord blood and throat secretion in the study group byvaginal delivery and cesarean section. The outcomes of HPV-positive pregnancy such as spontaneous abortion,premature delivery, premature rupture of fetal membrane, limited fetal growth, and neo-natal respiratory distress syndrome were significantly higher in the study group than group. The rupture of membranes time was related to the neonatal infection of HPV. ConclusionThe transmission of HPV in mother- to-child transmission cannot be completely avoided by deliverymodes. It can also be transmitted vertically through the cord blood, blood, amniota ,and horizontally by breast feeding.

关 键 词：人乳头状瘤病毒 妊娠期 母婴传播 胎婴儿影响 

分 类 号：R714.25[医药卫生—妇产科学]