透明质酸锌凝胶联合复方倍他米松注射液对增生性瘢痕患者预后、CD90及TGF-β_1阳性表达率的影响  

Effect of Hyaluronic acid combined with Compound Betamethasone injection on prognosis and expression levels of CD90 and TGF--β_1 in patients with hypertrophic scar

作　　者：汪阳[1] 张颖[2] 田婧[3] 

机构地区：[1]西安市中心医院烧伤整形科,西安710000 [2]西安市中心医院重症医学科,西安710000 [3]德阳市人民医院神经内科,四川德阳618000

出　　处：《中国医学前沿杂志（电子版）》2017年第10期213-216,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的分析透明质酸锌凝胶联合复方倍他米松注射液对增生性瘢痕患者预后、CD90及转化生长因子-β_1(transforming growth factor-β_1,TGF-β_1)阳性表达率的影响。方法选取西安市中心医院2016年3月至2016年12月收治的79例增生性瘢痕患者为研究对象。按照随机双盲的原则将入选患者分为试验组(39例)和对照组(40例)。对照组患者采用复方倍他米松注射液治疗,试验组患者在对照组治疗基础上加用透明质酸锌凝胶治疗。比较两组患者治疗前后CD90和TGF-β_1阳性表达率及预后的差异。结果治疗前两组患者CD90和TGF-β_1阳性表达率均无显著差异(P>0.05);治疗后,两组患者CD90和TGF-β_1阳性表达率均显著降低,且试验组患者CD90和TGF-β_1阳性表达率均显著低于对照组(P<0.05)。试验组患者治疗有效率显著高于对照组(P<0.05)。结论透明质酸锌凝胶联合复方倍他米松注射液可以显著降低增生性瘢痕患者CD90和TGF-β_1的阳性表达率,提高治疗效果,改善患者预后,值得临床推广。Objective To explore the effect of Hyaluronic acid combined with Compound Betamethasone on prognosis and expression levels of CD90 and TGF-β1 in patients with hypertrophic scar. Method 79 cases of hypertrophic scar patients treated in Xi＇an City Center Hospital from March 2016 to December 2016 were selected as the research object. According to the principle of random double blindness, the patients were divided into experimental group（39 cases） and control group（40 cases）. Treatment group patients were treated with Hyaluronic acid combined with Compound Betamethasone injection, control group patients were treated with Compound Betamethasone injection alone. The positive rates of CD90 and TGF-β1 and the prognosis of the two groups of patients before and after treatment were compared. Result Before treatment, there was no significant difference in the positive expression rate of CD90 and TGF-β1 between the two groups（P〈0.05）. After treatment, the positive expression rates of CD90 and TGF-β1 in the two groups were significantly reduced, and the expression rate in the experimental group was less than that in the control group（P〈0.05）. The effective rate of the patients in the test group was significantly higher than that in the control group（P〈0.05）. Conclusion Hyaluronic acid combined with Compound Betamethasone injection can significantly reduce the positive expression rate of CD90 and TGF-β1 in patients with hypertrophic scar, improve the therapeutic effect and the prognosis of patients, worthy of promotion.

关 键 词：透明质酸锌凝胶 倍他米松 增生性瘢痕 预后 CD90 转化生长因子-β1 

分 类 号：R622[医药卫生—整形外科]