丹参多酚酸盐治疗冠心病心绞痛的疗效及其对血液流变学、氧化应激的影响  

Treatment effect of salvianolateand its influence on the hemorheology and oxidative stress in angina pectoris patients

作　　者：邱丹[1] 王凡 赵涛[1] 

机构地区：[1]简阳市人民医院,四川简阳641400

出　　处：《安徽医药》2018年第1期147-151,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨丹参多酚酸盐治疗冠心病心绞痛的疗效及其对血液流变学、氧化应激的影响。方法选择2014年2月—2016年2月住院治疗的冠心病心绞痛患者110例,随机分为观察组55例及对照组55例。对照组接受临床常规治疗,观察组在常规治疗基础上加入丹参多酚酸盐治疗,均治疗2个月。治疗8周后评估两组患者的临床症状变化情况,应用彩色多普勒超声诊断仪检测心功能参数,抽取外周静脉血检测血液流变学参数及氧化应激指标含量。结果治疗8周后,两组的临床症状、心功能参数、血液流变学状态及氧化应激程度均较治疗前优化(P<0.05)。其中观察组的心绞痛发作次数、单次发作持续时间少于对照组,疼痛程度轻于对照组(P<0.05);超声心电图参数左室舒张末期容积(EDV)、收缩末期容积(ESV)水平低于对照组,左室射血分数(LVEF)水平高于对照组(P<0.05);血液流变学参数全血黏度高切/低切、血浆黏度、红细胞聚集指数水平低于对照组(P<0.05);氧化指标丙二醛(MDA)、脂质过氧化物(LPO)含量低于对照组,抗氧化指标超氧化物歧化酶(SOD)、总抗氧化力(TAC)含量高于对照组(P<0.05)。结论丹参多酚酸盐治疗冠心病心绞痛的疗效确切,在降低患者血黏度、氧化应激程度方面具有优势。Objective To study the treatment effectof salvianolate and its influence on the hemorheology and oxidative stress in angina pectoris patients. Methods One hundred and ten angina pectoris patients treated in Jianyang People's Hospital during February 2014 to February 2016 were randomized into observation group and control group,each with fifty-five cases. Patients in control group were treated with routine treatment for two months and those in observation group received salvianolate plus routine treatment for two months.After two-month treatment,clinical symptoms of the two groups were evaluated,the parameters of heart function were detected by color Doppler ultrasound,and the blood rheology parameters and contents of oxidative stress indexes were detected from peripheral venous blood. Results After eight-week treatment,the clinical symptoms,cardiac function parameters,blood rheology parameters and contents of oxidative stress indexes in bothgroups were better than those before treatment( P < 0. 05). Angina frequency andsingle seizure duration were less in observation group than in control group; degree of pain was milder in observation group than in control group( P <0. 05). Left ventricular end diastolic volume parameters such as end diastolic volume( EDV),end-systolic volume( ESV) levels were lower in observation group than in control group; left ventricular ejection fraction( LVEF) level was higher in observation group than in control group( P < 0. 05). Blood rheology parameters such as blood viscosity high-shear/low-shear,plasma viscosity,erythrocyte aggregation index levels were lower in observation group than in control group( P < 0. 05). Oxidation parameters such as malondialdehyde( MDA),lipid peroxide( LPO) contents were lower in observation group than in control group; antioxidant indexes such as superoxide dismutase( SOD) and total antioxidative capacity( TAC) were higher in observation group than in control group( P < 0. 05). Conclusions Effect of salvianolate in treating angina pectoris patients is go

关 键 词：冠心病心绞痛 丹参多酚酸盐 血液流变学 氧化应激 

分 类 号：R541.4[医药卫生—心血管疾病]