早期静注人免疫球蛋白治疗重症手足口病疗效分析  

Curative Effect of Early Intravenous Immunoglobulin on Severe Hand-Foot-Mouth Disease

作　　者：王浩[1] 高淑林[1] 

机构地区：[1]河北北方学院附属第一医院感染科,河北张家口075000

出　　处：《河北北方学院学报（自然科学版）》2017年第12期44-46,共3页Journal of Hebei North University:Natural Science Edition

摘　　要：目的探讨人免疫球蛋白早期治疗重症手足口病的临床效果。方法 150例重症手足口病患儿随机分为观察组和对照组各75例,对照组患儿给予抗病毒、消炎及提高免疫力类药物常规治疗,辅以营养支持和临床护理,观察组患儿在对照组常规治疗、护理基础上采用人免疫球蛋白静脉注射。分析2组患儿热峰(℃)、热程、惊跳、皮疹消退时间、住院天数及死亡率指标变化,评定疗效。结果治疗后,观察组患儿住院天数显著少于对照组(P<0.05),后遗症发病率显著低于对照组(P<0.05)。观察组患儿治疗总有效率、口腔溃疡愈合时间和食欲改善时间均显著优于对照组(P<0.05)。结论重症手足口病早期静注人免疫球蛋白临床疗效显著优于传统治疗,值得推广。Objective To discuss the clinical effect of human immunoglobulin in the early treatment of severe hand-foot-mouth disease.Methods 150 children with severe hand-foot-mouth disease were randomly divided into two groups(75 cases in each group).The control group were given anti-virus,antiinflammatory and immune therapy.The observation group were treated with human immunoglobulin by intravenous injection on the basis of routine nursing care in the control group.The changes of heat peak(℃),heat stroke,scare,rash subsided time,hospital stay and mortality were analyzed statistically.The efficacy of the two groups was evaluated.Results After treatment,hospitalization day in the observation group was significantly less than that in the control group(P<0.05);and the incidence of sequelae was significantly lower(P<0.05).The total effective rates of treatment,the healing time of oral ulcer and the time of improvement of appetite were significantly better than those of the control group(P<0.05).Conclusion The clinical efficacy of early intravenous injection of immunoglobulin on severe handfoot-mouth disease was significantly better than that of traditional therapy,so it is worth promoting.

关 键 词：免疫球蛋白 手足口病 口腔溃疡 

分 类 号：R725.1[医药卫生—儿科]