超顺磁Fe_3O_4纳米粒子的制备及弛豫性能  

Synthesis of Superparamagnetic Fe_3O_4 Nanoparticles and Its Relaxation Properties

作　　者：肖旺钏[1] 纪孝峰[2] 郑英 范彩霞[3] 赖文忠[1] 赵炎 罗菊香[1] 郑可利[1] 

机构地区：[1]三明学院资源与化工学院,三明365004 [2]三明市第一医院普外科,三明365004 [3]汕头大学医学院,汕头515041

出　　处：《人工晶体学报》2017年第12期2478-2484,共7页Journal of Synthetic Crystals

基　　金：福建省科技厅引导性项目(2015Y0077);福建省卫生教育联合攻关计划项目(WKJ-FJ-36);福建教育厅科技项目(JA12299);福建省自然科学基金(2015J01567);汕头大学医学院博士后基金;韶关市科学计划项目(卫)(2013-CX/K191)

摘　　要：采用简单的共沉淀法制备聚丙烯酸包覆、良好亲水性的Fe_3O_4纳米粒子,研究了不同Fe^(2+)和Fe^(3+)比例对所得纳米粒子的影响。高分辨率透射电镜和X-射线衍射分析证实所得产物为Fe_3O_4,红外光谱分析和热重分析表明微粒表面成功包覆聚丙烯酸。纳米粒子的粒径大小和分布用透射电镜分析,平均晶粒大小用X-射线衍射分析。结果表明,Fe^(2+)∶Fe^(3+)加入摩尔比1∶1.5、1∶1.75和1∶2所得3个纳米颗粒的透射电镜分析平均粒径分别为7.2 nm、6.7 nm和8.3nm,X-射线衍射分析平均晶粒大小分别为9.1 nm、8.2 nm和9.1 nm。激光粒度仪分析表明所得样品均含有部分大粒径的颗粒,应是颗粒出现部分团聚。磁性分析证实所得样品具有良好的超顺磁性。弛豫性能分析表明1∶1.5样品适合用于T1造影剂,1∶1.75和1∶2适合用于T2造影剂。该研究可为磁共振造影剂的性能优化提供参考。Superparamagnetic Fe304 nanoparticles with polyacylic acid coating and high hydrophilicity were synthesized by simple coprecipitation method. The influence of Fe2＋ ： Fe3＋ （mole ratio ） on the nanoparticle size was investigated. The crystal phase of Fe304 was confirmed by high resolution transmission electron microscopy and X-ray diffraction analysis. Infrared spectrum and thermogravimetric analysis indicate that poly acrylic acid is successfully coated onto the surface of the nanoparticles. The size of particles and their distribution is obtained from TEM. Average crystal size is infered from X-ray diffraction analysis. The average particles size from TEM and XRD are 7.2 urn, 6.7 nm, 8.3 nm and 9. 1 nm, 8.2 nm, 9. 1 nm, respectively, corresponding to Fe2＋： Fe3＋ = 1： 1.5, 1：1.75 and 1：2. Dynamic laser scatter analysis reveals that it has some larger particles. The nanoparticles show superparamagnetic properties under room temperature. Relaxation analysis indicates that the sample 1： 1. 5 is more suitable for TI contrast agents and 1 ： 1.75 and 1 ： 2 are for T2 ones. It provides a new way for the optimization of the MR contrast agents.

关 键 词：FE3O4纳米粒子 共沉淀 超顺磁 磁共振造影剂 弛豫性能 

分 类 号：TB332[一般工业技术—材料科学与工程]