门诊输血重型β地中海贫血患者不规则抗体和自身抗体检测  

Irregular antibodies and autoantibodies in transfused outpatients with β thalassemia major

作　　者：程道胜[1] 李伟超 任伟超 温俊杰[1] 黄青柳 李春娇[1] 

机构地区：[1]江门市中心医院输血科,广东江门529030

出　　处：《临床血液学杂志（输血与检验）》2017年第6期962-965,共4页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的:探讨长期门诊输血的重型β地贫患者血型不规则抗体和自身抗体阳性率及特异性。方法:采用微柱凝胶法检测在门诊长期反复输血的122例重型β地贫患者血型不规则抗体和自身抗体,并鉴定其特异性。结果:重型β地贫患者血型不规则抗体阳性10例(8.26%),自身抗体阳性4例(3.30%)。有7例患者检出一种不规则抗体,分别是抗-E 5例、抗-c和抗-Fyb各1例,其他3例检出混合抗体,分别是抗-E/c 2例,抗-C/e 1例。Rh血型抗体90%,其中抗-E占(77.78%)。结论:反复输血的重型β地贫患者可产生自身抗体和不规则抗体,不规则抗体主要是Rh血型抗体,尤以抗-E为主。Objective：To observe the positive rates and specificity of irregular antibodies and autoantibodies in patients withβthalassemia major who had received long-term transfusion therapy in out-patient.Method：The irregular antibodies and autoantibodies in 122 patients were screened and identified by microcolumn gel anti-globulin technique.Result：Among these patients withβthalassemia major,10 cases（8.26%）were reported to have irregular antibodies positive and 4（3.30%）have autoantibodies.Seven cases exhibited single irregular antibody which was anti-E in 5 cases,anti-c in 1 and anti--Fyb in 1,respectively.Another 3 cases showed double antibodies which were anti-E/c in 2 and anti-C/e in 1,respectively.Rh antibodies were 90%in all antibodies and in which anti-E was 77.78%.Conclusion：The outpatients withβthalassemia major who had received long-term transfusion therapy may have high rates of irregular antibodies and autoantibodies.Rh antibodies,especially the anti-E,showed the highest frequency.

关 键 词：Β地中海贫血 不规则抗体 自身抗体 微柱凝胶抗球蛋白法 

分 类 号：R457.1[医药卫生—治疗学] R446.9[医药卫生—临床医学]