10味中药对耐药性鲍曼不动杆菌抑菌效果的实验研究  

Antimicrobial effect of 10 Chinese herbs on drug-resistant Acinetobacter baumannii:an experimental study

作　　者：赵娜[1] 农凤鸣 黄燕[3] 韦莹慧[3] 唐玉莲[1] 黄跃斌[1] 汤丽霞[1] 

机构地区：[1]右江民族医学院,广西百色533000 [2]广西壮族自治区百色市食品药品检验所,广西百色533000 [3]右江民族医学院附属医院,广西百色533000

出　　处：《湖南中医杂志》2017年第12期142-144,共3页Hunan Journal of Traditional Chinese Medicine

基　　金：2013年中医药民族医药继承创新工程立项课题(编号:GZZC13-22)

摘　　要：目的:观察黄连等10味中药对耐药性鲍曼不动杆菌的体外抑菌效果,为临床治疗寻找新的思路和方向。方法:选用黄连、黄柏、黄芩、白头翁、大青叶、千里光、板蓝根、败酱草、蒲公英和金银花共10味中药,采用水煎法提取其有效成分,测定采用K-B法提取物对耐药性鲍曼不动杆菌的体外抑菌效果。结果:黄连、黄芩在3种菌液浓度均有不同程度的抑菌效果。而菌液浓度为0.5g/L和0.25g/L时抑菌效果更佳,千里光在菌液浓度为0.25g/L时有抑菌效果。结论:10味中药中黄连、黄芩2味中药对耐药性鲍曼不动杆菌的抑菌作用明显,而其他筛选的中药则抑菌作用不明显。Objective：To investigate the in vitro antimicrobial effect of 10 Chinese herbs including Coptis chinensis on drug-resistant Acinetobacter baumannii,and to provide new thoughts and directions for clinical treatment.Methods：Coptis chinensis,Phellodendri Chinensis Cortex,Scutellaria baicalensis,Pulsatilla chinensis,Folium Isatidis,groundsel,Radix Isatidis,Thlaspi arvense Linn.,dandelion,and Lonicera japonica were selected,and the method of decoction was used to extract effective constituents.The K-B method was used to evaluate the in vitro antimicrobial effect of extracts on drug-resistant Acinetobacter baumannii.Results：Coptis chinensis and Scutellaria baicalensis had varying degrees of antimicrobial effect at three different concentrations of bacterial solution,with excellent antimicrobial effects at the concentrations of 0.5 g/L and 0.25 g/L,while groundsel had an antimicrobial effect at a concentration of 0.25 g/L.Conclusion：Coptis chinensis and Scutellaria baicalensis have a marked antimicrobial effect on drug-resistant Acinetobacter baumannii,and the other eight Chinese herbs do not have a marked antimicrobial effect.

关 键 词：中药 耐药性鲍曼不动杆菌 体外抑菌 实验研究 

分 类 号：R285.5[医药卫生—中药学]