外阴硬化性苔癣的研究进展  

Research progress of vulvar lichen sclerosus

作　　者：杨欢[1] 李成志[1] 

机构地区：[1]重庆医科大学生物医学工程学院省部共建国家重点实验室培育基地-重庆市超声医学工程重点实验室重庆市生物医学工程学重点实验室,重庆400016

出　　处：《重庆医科大学学报》2017年第12期1531-1535,共5页Journal of Chongqing Medical University

基　　金：国家科技支撑资助项目(编号:2011BAI14B00);国家973计划资助项目(编号:2011CB707900)

摘　　要：外阴硬化性苔癣(vulvar lichen sclerosus,VLS)是一种生殖器皮肤与黏膜慢性炎症性疾病。尽管大量研究表明自身免疫、遗传、激素和感染与疾病的发病有关,但确切的病因仍不清。局部使用强效的糖皮质类固醇激素治疗是疾病的主要治疗方式,聚焦超声治疗也在临床上广泛使用,并取得令人满意的临床疗效。VLS难以根治,且无论何种治疗方式,均有复发的可能。近年不断有新的关于疾病病因和发病机制的研究,同时也提出了许多新的治疗方式,现对该病的研究进展做一综述。Vulvar lichen sclerosus（VLS）is a chronic inflammatory disease relating to genital skin and mucosa.There are many factors such as autoimmune,genetic,hormonal and infection factors associated with paroxysm,but its etiology is still unclear.Ultra-potent topical corticosteroids（TCSs）are the first-line treatment for VLS.Focused ultrasound is widely used in clinic,and has obtained satisfactory clinical efficacy.As it is difficult to treat VLS,all kinds of treatment have the possibility of recurrence.In recent years,many new researches on the etiology and pathogenesis of VLS have been proposed and many new treatments have been put forward at the same time.This paper reviews the research progress of VLS.

关 键 词：外阴硬化性苔癣 病因 发病机制 治疗 

分 类 号：R711.72[医药卫生—妇产科学]