小球腔菌属次级代谢产物的化学及其生物学活性研究进展  

Secondary Metabolites Produced by Leptosphaeria and Their Bioactivities

作　　者：刘丛丛 韩俊杰[2,3] 刘宏伟 

机构地区：[1]河北大学生命科学学院,保定071002 [2]中国科学院微生物研究所,北京100101 [3]中国科学院大学存济医学院,北京100049

出　　处：《天然产物研究与开发》2017年第12期2163-2174,共12页Natural Product Research and Development

基　　金：国家自然科学基金(21602247)

摘　　要：小球腔菌可引发油菜黑胫病等给农业造成严重的经济损失。该属真菌的次级代谢产物研究开始较早,化合物分离工作主要围绕黑胫病致病菌株,研究发现该属真菌的次级代谢产物十分丰富,许多化学结构新颖、具有显著生物活性的化合物均被发现。为使该属的真菌资源得到充分的开发与利用,本文对40多年来报道的小球腔菌属次级代谢产物的化学及其生物学活性进行了较为全面的综述。Leptosphaeria causes blackleg of rapeseed/eanola crops and brings serious yield losses in agriculture. The study on secondary metabolites produced by Leptosphaeria started very early, the isolation work was mainly related to blackleg pathogenic strains. The present study demonstrated that the secondary metabolites of Leptosphaeria were rich, furthermore, many compounds possessed novel structure and notable biological activities. Here were viewed the chemical structure and bioactivities of secondary metabolites produced by Leptosphaeria during the past 40 years to draw more at- tention to the fungus.

关 键 词：小球腔菌属 茎点霉属 萜 聚酮 非核糖体多肽 

分 类 号：R284[医药卫生—中药学]