乙醛脱氢酶2基因多态性与早发冠心病的相关性研究  

Relativity of gene polymorphism of aldehyde dehydrogenase 2 to premature coronary heart disease

作　　者：江玲[1] 李玉茜[1] 田建伟[1] 刘沛 王林海 刘朝中[1] 

机构地区：[1]安徽医科大学空军临床学院心脏中心内科,北京100142 [2]鑫诺美迪基因公司,北京100142

出　　处：《解放军医学杂志》2017年第12期1083-1087,共5页Medical Journal of Chinese People's Liberation Army

基　　金：全军"十一五"科技攻关项目(06G009);2015年度科技创新基地培育与发展专项项目(Z151100001615087)~~

摘　　要：目的探讨中国汉族人群中,乙醛脱氢酶2(ALDH2)基因多态性与早发冠心病之间的关系。方法本研究共纳入505例患者,根据冠脉造影结果确诊冠心病患者375例及非冠心病患者130例,其中冠心病患者又分为早发冠心病组150例(男<55岁,女<65岁)和晚发冠心病组225例(男≥55岁,女≥65岁)。另外,将505例患者根据饮酒后是否面红分为面红组135例和非面红组370例,根据是否有习惯性饮酒分为饮酒习惯组189例和无饮酒习惯组316例。通过Sanger测序的方法对ALDH2基因的多态性进行分析。结果 ALDH2基因型分布在早发冠心病组与晚发冠心病组间,以及冠心病组与非冠心病组间差异均无统计学意义(P>0.05),logistics回归校正性别、年龄、抽烟、饮酒、体重指数(BMI)、高血压、糖尿病、高脂血症、冠心病家族史等因素后,ALDH2基因不是早发冠心病和冠心病的易感因素(P=0.729,OR=1.098,95%CI 0.648~1.859;P=0.581,OR=1.156,95%CI 0.692~1.930)。ALDH2突变型(GA+AA)发生率在饮酒面红组中(67.4%)明显高于非面红组(10.5%,P<0.01),在无饮酒习惯组中(29.7%)高于有饮酒习惯组(19.1%,P<0.01)。结论 ALDH2基因多态性不是中国汉族人群中早发冠心病及冠心病发病的危险因素,饮酒面红与ALDH2突变型基因有关。Objective To investigate the relationship between aldehyde dehydrogenase 2 （ALDH2） gene polymorphism and premature coronary heart disease （CHD） in Chinese Han population. Methods A total of S05 patients were enrolled in the present study. Of them, 375 were definitely diagnosed as CHD and another 130 were excluded from CI-ID by coronary angiography. Coronary heart disease patients were divided into premature coronary heart disease （male 〈55 years, female 〈65 years） group （n= 150） and late onset coronary heart disease （male 1〉 55 years, female I〉 65 years） group （n=225）; According to whether after drinking flushing, the enrolled 505 patients were divided into alcohol flushing syndrome（AFS） group （n=135） and no AFS group （n=370）; According to whether used to drinking, they were divided into accustomed to drinking group （n=189） and no drinking custom group （n=316）. The ALDH2 gene polymorphism was analyzed by sanger sequencing. Results There was no significant difference in the distribution ofALDFI2 genotype between the patients with premature CHD and late-onset CHD, also between CHD and non-CHD （P〉0.05）. The logistic regression analysis showed that ALDH2 gene was not a predisposing factor of PCHD and CHD after adjusting for gender, age, smoking, drinking, body mass index （BMI）, hypertension, diabetes, hyperlipidemia and family history of CHD （P=0.729, OR=1.098, 95%CI 0.648-1.859; P=0.581, OR=1.156, 95%CI 0.692-1.930）. The incidence of ALDH2 mutant （GA＋AA） was significantly higher in AFS group than in no AFS group （67.4% vs. 10.5%, P〈0.01）. The gene mutation frequency was markedly higher in no drinking custom group than in accustomed to drinking group （29.7% vs. 19.1%, P〈0.01）. Conclusions No obvious correlation exists between ALDH2 gene polymorphism and the incidence of premature CHD or the onset of CHD in Chinese Han population. There is a certain relationship between ALDH2 mutant gene and AFS.

关 键 词：早发冠心病 乙醛脱氢酶2 多态性 单核苷酸 基因 

分 类 号：R541.4[医药卫生—心血管疾病]