解毒祛风通络方治疗湿热痹阻型类风湿性关节炎的临床研究  

Clinical Study on Jiedu Qufeng Tongluo Therapy(解毒祛风通络方) in Treatment of Dampness-Heat Blockage Type of Rheumatoid Arthritis

作　　者：李萌萌[1] 刘道银[1] 张传英[2] 

机构地区：[1]亳州市人民医院,安徽亳州236800 [2]安徽中医药大学,安徽合肥230038

出　　处：《中医药导报》2017年第24期83-86,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：安徽省教育厅基金资助项目(KJ2012A156)

摘　　要：目的:观察解毒祛风通络方治疗湿热痹阻型类风湿性关节炎的临床疗效。方法:将120例湿热痹阻型类风湿性关节炎患者随机分为两组各60例。对照组采用来氟米特片及醋氯芬酸片治疗,治疗组采用解毒祛风通络方及来氟米特片治疗。比较两组治疗前后血清C-反应蛋白(CRP)、红细胞沉降率(ESR)、白细胞介素-1(IL-1)、类风湿因子(RF)水平及临床症状的变化情况,并对两组临床疗效进行评价。结果:与治疗前比较,治疗后两组血清CRP、ESR、IL-1、RF水平及中医证候积分均下降,且治疗组上述指标均低于对照组,差异有统计学意义(P<0.05);治疗组总有效率为93.3%,对照组总有效率为71.7%,治疗组优于对照组,差异有统计学意义(P<0.05)。结论:解毒祛风通络方治疗湿热痹阻型类风湿性关节炎有较好临床疗效,可缓解临床症状,促进患者身体恢复。Objective： To observe the clinical efficacy of Jiedu Qufeng Tongluo therapy （解毒祛风通络方, JDQFTLT） in treatment of dampness-heat blockage type of rheumatoid arthritis. Methods： 120 patients with dampness-heat blockage type of rheumatoid arthritis were randomly divided into two groups, 60 cases in each. Control group took leflunomide tablets and aceclofenac tablets, research group took JDQFTLT and leflunomide tablets. The C-reactive protein （CRP）, erythrocyte sedimentation rate （ESR）, interleukin-1 （IL-1）, rheumatoidfactor （RF） levels and changes of clinical symptoms of two groups before and after treatment were compared. Results： Compared with pre-treatment, the serum CRP, ESR, IL-1, RF levels and TCM symptom scores of two groups decreased, and above-mentioned indexes of research group were lower than control group （P〈0.05）; The total ef- fective rate of research group was 93.3%, significantly higher than 71.7% of control group （P〈0.05）. Conclusion： Jiedu Qufeng Tongtuo therapy for dampness-heat blockage type of rheumatoid arthritis can significantly increase clinical efficacy, relieve clinical symptom, promote body recovery.

关 键 词：类风湿性关节炎 湿热痹阻 解毒祛风通络方 

分 类 号：R255.6[医药卫生—中医内科学]