火针对ICR小鼠耳廓痤疮模型影响的实验研究  

Experimental Study on the Effect of Fire Acupucture Therapy for Acne Model Of ICR Mice

作　　者：陈茜 刁庆春[1] 韩晓凤[1] 饶燕[1] 梁成萍 江雪[1] 陶春蓉[1] 

机构地区：[1]重庆市中医院/重庆市第一人民医院皮肤科,重庆400011

出　　处：《四川中医》2017年第12期45-47,共3页Journal of Sichuan of Traditional Chinese Medicine

基　　金：重庆市基础与前沿研究计划项目(编号:cstc2016jcyj AX0002;编号:cstc2015jcyj A10126)

摘　　要：目的:观察火针治疗ICR小鼠痤疮模型的疗效。方法:ICR小鼠随机分为4组:PBS对照组、模型组、普通针组及火针组,每组10只。通过耳廓皮内注射痤疮丙酸杆菌建立ICR小鼠痤疮模型,造模后普通针组及火针组分别给予普通针及火针治疗,每隔24小时治疗1次,共治疗2次;PBS对照组及模型组不治疗。观察耳廓红斑及厚度变化,并进行耳廓皮损组织病理检查。结果:模型组注射部位24小时后出现明显红斑肿胀,呈痤疮炎症样皮损;火针治疗后小鼠耳廓组织的红斑及厚度明显减轻(P<0.05),炎症改善明显;病理显示真皮中炎症细胞及皮脂腺增生明显减少,血管扩张及组织水肿明显好转。结论:火针治疗可以有效改善小鼠痤疮模型的炎症及皮脂腺增生,说明火针治疗痤疮疗效确切。Objective ： To observe the effect of fire acupucture therapy for the ache model of ICR mice. Methods ： ICR mice were randomly divided into 4groups as follows （10mice/group） ： PBS controlled group, model group, common needle therapy group, fire acupucture therapy group. The ICR mouse ear acne model was established by intradermal injection of Propionibacteri- um acnes. Every 24hours different groups were given ordinary needle or acupucture therapy intervention treatment, a total of 2times. The PBS controlled group and the model group were not treated. The changes of the thickness of the auricle tissue wer~ recorded and histopathological examination were taken from the auricle lesion. Results ： Morphological observation showed that fire acupucture therapy exerted anti-inflammatory effects against P. Acnes, the decrease of the auricle thickness and erythema in the fire acupucture therapy group was more obvious. The histopathological examination revealed that the expansion of blood vessels and tissue edema in the fire acupucture therapy group were significantly reduced, and inflammatory cells and sebaceous gland hy- perplasia were reduced also. Conclusion： Fire acupucture therapy can effectively improve inflammation and sebaceous gland hy- perplasia of the mouse acne model. This suggests fire acupucture therapy can potentially be used to effectively treat acne.

关 键 词：火针治疗 痤疮丙酸杆菌 小鼠痤疮模型 

分 类 号：R285.5[医药卫生—中药学]