溴吡斯的明联合酚苄明治疗脊髓损伤后神经源性膀胱疗效观察  

Pyridostigmine Bromide Combined with Phenoxybenzamine in Treatment of Neurogenic Bladder after Spinal Cord Injury

作　　者：童晓轩 黄海艳 方婷 董冉 

机构地区：[1]湘潭市第六人民医院,湖南湘潭411100

出　　处：《按摩与康复医学》2018年第1期61-63,共3页Chinese Manipulation and Rehabilitation Medicine

摘　　要：目的:观察溴吡斯的明联合酚苄明在脊髓损伤后神经源性膀胱患者中的治疗效果。方法:将40例脊髓损伤后神经源性膀胱患者随机分为治疗组和对照组各20例,对照组采用膀胱功能训练,治疗组则在膀胱功能训练基础上配合服用溴吡斯的明(30/60mg,tid)和酚苄明(10mg,tid),采用尿动力学检查评定膀胱容量、膀胱逼尿肌压力、尿道压力、膀胱残余尿量的改善情况。结果:治疗组尿动力学检查各项指标改善程度均显著优于对照组(P<0.05)。结论:溴吡斯的明联合酚苄明能有效增加膀胱逼尿肌及膀胱压力、降低尿道括约肌压力,促进尿液排出,减少残余尿量,在神经源性膀胱治疗中取得良好效果。Objective： To observe the efficacy of pyridostigmine bromide combined with phenoxybenzamine in treatment of neurogenic bladder after spinal cord injury. Methods： 40 cases of patients with neurogenic bladder after spinal cord injury were randomly divided into treatment group （20 cases） and control group （20 cases）, the control group received bladder functional training while treatment group combined with orally taking pyridostig-mine bromide （30/60mg, tid） and phenoxybenzamine （10mag, tid）, evaluated the improvement of bladder capacity, detrusor pressure, urethral pressure and residual urine volume by urodynamic examination. Results： The improvement of every index of urodynamic examination in treatment group was significantly better than that of control group （P〈0.05）. Conclusion： Pyridostigmine bromide combined with phenoxybenzamine can effectively increase detrusor and bladder pressure, decrease urethral sphincter pressure and promote urine excretion, reduce residual urine volume, which can achieve a great effect on neurogenic bladder.

关 键 词：脊髓损伤 神经源性膀胱 澳毗斯的明 酚苄明 尿动力学 疗效 

分 类 号：R651.2[医药卫生—外科学]