中西医结合治疗滴虫性阴道炎的临床疗效分析  

Clinical analysis of treating trichomonas vaginitis with traditional Chinese medicine and western medicine

作　　者：仇志琴[1] 虞丰[1] 赵呈雷[2] 

机构地区：[1]南京医科大学附属无锡二院妇产科,江苏无锡市214002 [2]南京中医药大学附属中西医结合医院分子与细胞实验室

出　　处：《热带病与寄生虫学》2017年第4期219-221,230,共4页Journal of Tropical Diseases and Parasitology

基　　金：江苏省中医药局科研项目(N0.Z2011189)

摘　　要：目的考察硝基咪唑类药物与中药联合治疗滴虫性阴道炎的疗效及相关临床指标。方法选取2014年1月至2015年12月无锡市第二人民医院治疗的滴虫性阴道炎患者140例,随机分为对照组与观察组,各70例。对照组给予替硝唑口服、甲硝唑泡腾片阴道给药治疗;观察组给予与对照组同样药物,并加以中药外洗治疗。比较两组患者临床疗效、临床症状、阴道灌洗液细胞因子水平及不良反应发生情况。结果治疗7天后,观察组总有效率高于对照组,分别为100%与95.71%,且观察组临床痊愈率较对照组提高了10%。治疗后观察组分泌物镜检、脓性或泡沫样白带、尿频尿痛、外阴瘙痒症状均少于对照组,差异有统计学意义(P<0.05)。治疗后两组患者阴道灌洗液IL-2、IL-8、IL-13水平均显著下降,观察组的下降幅度高于对照组,差异具有统计学意义(P<0.05)。两组患者不良反应发生率差异无统计学意义(P>0.05)。结论硝基咪唑类药物联合中药外洗治疗滴虫性阴道炎,效果优于单一用药,且可更好改善阴道微环境炎性反应,安全性高,可在临床广泛使用。Objective To observe the clinical efficacies of treating trichomonas vaginitis using combined regimen of nitroimidazoles with traditional Chinese medicine. Methods One hundred and forty cases of trichomonas vaginitis treated in Wuxi Second People's Hospital between January 2014 and December 2015 were included and randomly divided into control group and observational group(n = 70 for each group). Patients in the control group were treated with oral tinidazole and vaginal metronidazole effervescent tablets,while those in the observational group were given additional external washing with traditional medicine on the basic treatment regimen prescribed as the control group. Then the two groups were compared concerning the clinical efficacies,clinical symptoms,cytokine levels of vaginal lavage fluid and adverse reactions. Results After 7 days of treatment,the total effective rate in the observational group was higher than that in the control group(100% vs. 95. 71%),and clinical recovery rate was 10% higher in the observational than in the control group. Microscopic examination indicated that patients in the observational group had lower purulent secretions or foamy leucorrhea,painful and frequent urination as well as pruritus vulvae than those in the control group(P < 0. 05). The levels of IL-2,IL-8 and IL-13 in the vaginal lavage fluid were significantly decreased in the two groups of patients following 2 weeks of treatment,and the decrease rate was higher in the observational group than in the control group(P < 0. 05). The difference not significant in incidences of adverse reactions between groups(P > 0. 05). Conclusion Combined nitromidazoles with traditional Chinese herbal medicine for trichomonas vaginitis may be wider clinical recommendation,for this regiment can be better than simple medication,and may improve the vaginal microenvironment and clinical safety.

关 键 词：滴虫性阴道炎 硝基咪唑类 中药 细胞因子 

分 类 号：R692.05[医药卫生—泌尿科学]