高迁移率族蛋白B1与肝纤维化的研究进展  

Research Progress of High Mobility Group Protein B1 and Hepatic Fibrosis

作　　者：谢华 何良梅 刘瑶[2] 张自翔[2] 

机构地区：[1]赣南医学院第一临床医学院,江西赣州341000 [2]赣南医学院第一附属医院,江西赣州341000

出　　处：《赣南医学院学报》2017年第6期1001-1004,共4页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：肝纤维化(hepatic fibrosis)是一种可逆性的创伤-修复反应,是各种慢性病发展为肝硬化、肝癌的必经过程,也是门静脉高压、腹水、肝性脑病、合成功能障碍和代谢能力受损等肝病终末期并发症的基础。目前尚无特效药物治疗。近年大量研究表明,高迁移率族蛋白B1(high mobility group box 1,HMGBl)与肝脏炎症及肝纤维化的发生发展有密切的关系。现就高迁移率族蛋白B1与肝纤维化的发病机制及其应用的研究进展作一综述。Hepatic fibrosis is a reversible injury-repair reaction.It is a necessary process for the development of various chronic diseases as cirrhosis and liver cancer,and also is the foundation of end-stage liver disease complications,such as portal hypertension,ascites,hepatic encephalopathy,metabolic synthesis dysfunction and impaired ability.There is no special drug therapy for liver fibrosis so far.In recent years,a large number of studies have shown that high mobility group B1 is closely related to the occurrence and development of liver inflammation and liver fibrosis.This article reviews the research progress on the pathogenesis and application of high mobility group protein B1 and hepatic fibrosis.

关 键 词：肝纤维化 高迁移率族蛋白B1 肝星状细胞 

分 类 号：R392.9[医药卫生—免疫学]