强直性脊柱炎的干细胞研究及其治疗应用  

Research and therapeutic applications of stem cells in ankylosing spondylitis

作　　者：冯新哲 徐卫东[1] 

机构地区：[1]第二军医大学附属长海医院关节骨病外科,上海200433

出　　处：《中华关节外科杂志（电子版）》2017年第6期661-665,共5页Chinese Journal of Joint Surgery(Electronic Edition)

摘　　要：强直性脊柱炎(AS)是一种主要以中轴关节受累的慢性、系统性、炎症性疾病,其发病原因尚不十分清楚。研究证实,遗传、环境和免疫因素在AS的发病中发挥重要作用。目前,人们针对此疾病的流行病学、发病机制、诊断、治疗等方面都有较为广泛和深入的研究,同时有大量研究成果发表。近年来,干细胞的研究作为科学研究的新方向,给人们研究AS的发病机制和治疗AS提供了新的思路。AS的干细胞研究虽起步较晚,但进展很快。同时,这一领域也存在诸多难题等待攻克。本文综述了AS发病过程中干细胞的功能研究,以及干细胞治疗AS的最新进展。为AS的诊断。Ankylosing spondylitis （ AS） is a chronic,systemic,inflammatory disease mainly involving the central axis joint .The etiology of the disease is not yet clear .Studies confirm that genetic ,environmental and immune factors play an important role in the pathogenesis of AS .At present ,people have had a wide range of in-depth studies on the epidemiology ,pathogenesis ,diagnosis and treatment of this disease ,with numerous research results published .In recent years ,the research of stem cells ,as the new direction of scientific research ,has provided a new idea for people to study the pathogenesis of AS and treat AS.Although stem cell research in AS started late ,it progressed rapidly.At the same time,there are many problems waiting to be overcome in this area .This paper reviewed the functional studies of stem cells in the process of AS and the latest advances in stem cell therapy for AS ,which provided evidence for the diagnosis ,treatment and prevention of AS .

关 键 词：脊柱炎 强直性 干细胞 研究 治疗 

分 类 号：R593.23[医药卫生—内科学]