拉莫三嗪代谢酶和转运体基因多态性对血药浓度的影响的研究进展  

Research Progress of the Effects of Polymorphic Metabolic Enzymes and Transporters on Lamotrigine Concentrations

作　　者：楼江[1] 林能明[1] 刘占利[2] 王刚[1] 王飞[1] 李晴宇[1] 陈玲[1] 严伟[1] 

机构地区：[1]杭州市第一人民医院药学部,杭州310006 [2]杭州市第一人民医院儿科,杭州310006

出　　处：《中国现代应用药学》2017年第12期1774-1778,共5页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省药学会医院药学专项科研自助基金(2016ZYY14);浙江省医药卫生科技计划项目(2018RC061)

摘　　要：拉莫三嗪是一线抗癫痫药物,临床疗效和不良反应个体差异大与血药浓度有关,近年来寻找拉莫三嗪血药浓度差异的原因是研究的热点。本综述探讨了代谢酶和转运体基因多态性对拉莫三嗪血药浓度的影响,以期为拉莫三嗪个体化治疗提供参考依据。Lamotrigine is used as a first-line therapeutic agent for the treatment of epilepsy. Large interindividual variability in clinical efficacy and adverse reactions of lamotrigine has been observed, it maybe associated with lamotrigine serum concentration. Recently, to search the variability has become a research focus in lamotrigine serum concentration. Through access to the domestic and foreign references in this paper, to investigate the effects of polymorphic metabolic enzymes and transporters on lamotrigine concentraions, and hope to provide reference for the individualized treatment of lamotrigine.

关 键 词：拉莫三嗪 代谢酶 转运体 基因多态性 血药浓度 

分 类 号：R969.1[医药卫生—药理学]