穴位刺激在脓毒症脏器损伤中的保护作用及机制  

Protective effects of acupuncture on organs in patients with sepsis and possible underlying mechanisms

作　　者：张艳芳[1] 余剑波[1] 

机构地区：[1]天津医科大学南开临床学院,天津市南开医院麻醉科,300100

出　　处：《国际麻醉学与复苏杂志》2017年第12期1143-1147,共5页International Journal of Anesthesiology and Resuscitation

摘　　要：背景中医对某些难治性疾病治疗具有独特疗效，其中穴位刺激已经被证实在脓毒症患者中有显著的器官保护作用，但机制尚不清楚。目的探讨穴位刺激对脓毒症患者的脏器保护作用及可能机制。内容脓毒症造成患者多个器官损伤，研究表明穴位刺激足三里或内关穴能明显提高患者肺、肝、肾、胃肠道和心脏等器官功能，其机制可能与多种细胞或调节因子有关，例如穴位刺激有助于调节促炎反应和抗炎反应失调、限制氧化应激损伤和细胞凋亡，同时减轻上皮细胞损伤和凝血功能紊乱。趋向尚需进一步研究优化穴位刺激中俞穴和刺激方式的选择，从而最大限度发挥其保护作用。Background Traditional Chinese medicine has special efficacy in the treatment of some intractable diseases. For instance, acupuncture has been demonstrated to protect organs from damage in patients with sepsis. The mechanisms underlying the effectiveness are not clear. Objective To review the effects of acupuncture on organs of patients with sepsis, and discuss possible mechanism underlying the effects. Content Patients with sepsis exhibit injury in multiple organs. Acupuncture at Tsusanli or Neiguan has been reported to significantly improve the pathology of lung, liver, kidney, gastrointestinal tract, and heart in sepsis, and to restore normal functions of these organs. These protective effects of acupuncture could be associated with its modulation of several cellular and molecular events. For instance, acupuncture helps maintain the balance between pro-inflammatory and anti- inflammatory processes, limits oxidation stress and apoptosis, and controls destruction of epithelia and disruption of coagulation. Trend Further studies are warranted to optimize the selection of acupoints and stimulating paradigm for acupuncture to maximally reverse the deleterious effects of sepsis not only on the aforementioned organs, but also on the brain and other organs.

关 键 词：脓毒症 穴位刺激 脏器保护 

分 类 号：R246[医药卫生—针灸推拿学]