硼替佐米所致62例不良反应文献分析  

Analysis of 62 cases of adverse drug reactions caused by Bortezomib

作　　者：王雪[1] 董迪[1] 甄健存[1] 

机构地区：[1]北京积水潭医院药学部,北京100035

出　　处：《中国医院药学杂志》2017年第24期2467-2470,2485,共5页Chinese Journal of Hospital Pharmacy

摘　　要：目的:调查国内外文献中硼替佐米所致不良反应的发生情况及其临床特点。方法:收集2003年至2017年国内外医学文献中报道的硼替佐米所致药物不良反应的病例报告。对患者年龄、用药情况、不良反应发生的时间和临床特点及转归进行统计和分析。结果:共有53篇报道文献纳入统计,涉及硼替佐米所致不良反应62例。其中男性37例,女性25例,不良反应临床表现复杂多样,且涉及多个系统/器官。其中,呼吸系统损害所占比例最大,达28.89%,其次为中枢及外周神经系统损害,占13.33%。结论:硼替佐米所致不良反应应引起临床高度重视,规范硼替佐米的用法用量、关注易发生不良反应的高风险人群,早期发现并给予对症治疗可将不良反应引起的损害降至最低。OBJECTIVE To investigate the occurrence and clinical characteristics of adverse reactions caused by bortezomib.METHODS Case reports of bortezomib induced adverse drug reactions were collected from medical literature in China and at abroad between 2003 and 2017.Data were analyzed in distribution of patient age,dosage of bortezomib,onset time and clinical characteristics of adverse drug reactions,consequence and prognosis.RESULTS A total of 53 articles were included,involving62 cases of adverse effects caused by bortezomib,including37 males and25 females.The clinical manifestations of adverse drug reactions were complicated and involving multiple systems/organs.Respiratory damage accounted for the largest proportion up to 28.89%,followed by the central and peripheral nervous systems,accounting for 13.33%.CONCLUSION Attentions should be paid to bortezomib induced adverse drug reactions to regulate the use of bortezomib.Early detection and symptomatic treatment can minimize damages.

关 键 词：硼替佐米 周围神经病变 急性肺损伤 多发性骨髓瘤 药物不良反应 

分 类 号：R969[医药卫生—药理学]