SH281基因多态性与超重、肥胖的相关性分析  

Association of SH2B1 gene polymorphism with overweight and obesity

作　　者：赵明伟[1] 高彬[1] 蔡婧[1] 明洁[1] 姬秋和[1] 

机构地区：[1]第四军医大学西京医院内分泌代谢科,西安710032

出　　处：《中华内分泌代谢杂志》2017年第12期1038-1042,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：陕西省科技统筹创新工程计划项目（2013KTZB03-02-01）

摘　　要：在西北人群中探讨SH2B衔接因子蛋白1（SH2B1）的基因多态性与超重、肥胖及相关代谢指标的相关性.基于2007年至2008年陕西省糖尿病流行病调查的社区人群2920例,其中男性1210例（超重635例,肥胖167例）,女性1711例（超重781例,肥胖212例）.应用基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）技术进行位点的检测分型.校正了年龄后,SH2B1基因单核苷酸多态性位点（rs7359397）和男性超重及肥胖有相关性,其中超重符合显性模型（P=0.02）、超显性模型（P=0.03）和log加性模型（P=0.025）;肥胖亦符合显性模型（P=0.0078）、超显性模型（P=0.0081）和log加性模型（P=0.015）.该位点多态性与男性体重指数、体脂含量、空腹胰岛素和稳态模型评估的胰岛素抵抗指数相关,与女性高密度脂蛋白胆固醇相关（P〈0.05）.在西北人群中SH2B1基因与男性超重、肥胖及相关代谢指标具有相关性.To investigate the association of SH2B1 gene rs7359397 polymorphism with overweight and obesity,as well as some related metabolic indicators in Northwest Chinese. Based on the cohort of China National Diabetes and Metabolic disorders Study（2007-2008） in Shanxi province, totally 1210（including 635 overweight and 167 obese） males and 1711（including 781 overweight and 212 obese） females were participated in this study. Matrix assisted laser desorption/ionization time-of-flight mass spectrometry（ MALDI-TOF MS） was adopted as the genotyping method. After adjusting for age, the single nucleotide polymorphism rs7359397 of SH2B1 was found to be associated with overweight and obesity in males. The correlation with overweight accords with the dominant（P=0. 02）, overdominant（P=0. 03）, and log-additive models（P=0. 025）, while the correlation with obesity accords with the dominant（P=0. 0078）, overdominant（P=0. 0081）, and log-additive models（P=0. 015）. rs7359397 showed to have a significant association with body mass index, body fat percentage, fasting serum insulin, homeostasis model assessment of insulin resistance in males;and high density lipoprotein-cholesterol in females（P〈0. 05）. The results show that SH2B1 rs7359397 polymorphism is associated with overweight, obesity, and related metabolic indicators in males of the population studied.

关 键 词：单核苷酸多态性 超重 肥胖 SH281基因 胰岛素 

分 类 号：R587.1[医药卫生—内分泌] R589.2[医药卫生—内科学]