有氧运动联合护理干预对肺癌化疗患者癌症相关性疲劳及免疫-炎性反应的影响  

Effects of aerobic exercises combined with nursing intervention on cancer-related fa- tigue and immune-inflammatory in the patients with lung cancer undergoing chemotherapy

作　　者：李三梅[1] 雷敏[1] 陈娜芬 康琼丹 

机构地区：[1]中国人民解放军第174医院,361000

出　　处：《国际护理学杂志》2017年第24期3325-3330,共6页international journal of nursing

摘　　要：目的 探讨有氧运动联合护理干预对肺癌化疗患者癌症相关性疲劳（CRF）及免疫-炎性反应的影响.方法 选取2014年4月～2016年12月该院肺癌化疗患者100例,随机分为观察组和对照组各50例.对照组给予常规护理,观察组给予有氧运动联合护理干预.采用Piper疲劳修订量表（RPFS）评估患者的疲乏程度,采用生活质量核心量表（QLQ-C30）评估患者的生活质量,并比较化疗前及化疗结束后2周患者的生活质量、CRF及血清免疫-炎性反应指标的变化情况.结果 干预后两组PFS总分及各维度评分均较干预前明显下降,且观察组显著低于对照组,差异有统计学意义（均P〈0.05）;生活质量评分及各功能评分均显著高于干预前,且观察组各功能评分及生活质量评分均显著高于对照组,差异均有统计学意义（均P〈0.05）;干预后两组患者CD3＋、CD4＋、CD4＋/CD8＋、NK细胞均显著降低（均P〈0.05或0.01）,而干预后观察组CD3＋、CD4＋、CD4＋/CD8＋、NK细胞水平均显著高于对照组,差异均有统计学意义（均P〈0.05或0.01）;与干预前比较,干预后两组患者NLR显著下降（P〈0.01）,观察组NLR、PLR均明显低于对照组,差异有统计学意义（均P〈0.05或0.01）.结论 有氧运动联合护理干预有效地缓解了肺癌化疗患者的CRF程度,提高了患者的生活质量,显著抑制了炎性反应,促进了细胞免疫功能的恢复.Objective To explore the effects of aerobic exercises combined with nursing intervention on canc-er-related fatigue （ CRF） and immune-inflammatory mediators in the patients with lung cancer undergoing chemothera-py. Methods A total of 100 patients receiving chemotherapy were randomly divided into observation group and control group, 50 cases of each group. The control group was given regular care, and the observation group was given a combi-nation of aerobic exercise and nursing intervention. The patient ＇ s fatigue was assessed using the Piper Fatigue Scale （RPFS）, and the quality of life was assessed using the Quality of Life Scale （QLQ-C30） . The quality of life, cancer-related fatigue and serum immune-inflammatory mediators were compared between the two groups before and 2 weeks af-ter chemotherapy. Results After intervention, the scores of PFS and each dimension of the two groups were significant-ly lower than those before intervention, and the scores of PFS and each dimensions of the observation group were signifi-cantly higher than those of the control group （ P〈0. 05 ） . The quality of life scores and function scores of the two groups were significantly higher than those before intervention. The quality of life scores and function scores of the observation group were significantly higher than those in the control group （ P〈0. 05 ） . After intervention, the levels of CD3＋, CD4＋, CD4＋/CD8＋ and NK cells were significantly decreased in the two groups （ P〈0. 05 or 0. 01 ） . The levels of CD3＋, CD4＋, CD4＋/CD8＋ and NK cells in the observation group were significantly higher than those in the control group （P〈0. 05 or 0. 01） . Compared with before intervention, the NLR were significantly decreased in the two groups after intervention （ P〈0. 01 ） , the NLR and PLR in the observation group were significantly lower than those in the con-trol group （ P〈0. 05 or 0. 01 ） . Conclusion Aerobic exercise combined with nursing intervention can effectively rel

关 键 词：肺癌 有氧运动 癌症相关性疲劳 免疫 炎症 

分 类 号：R473.73[医药卫生—护理学]