匹多莫德用于小儿慢性扁桃体炎的疗效及对患儿血清白细胞介素4和肿瘤坏死因子α水平的影响  

Efficacy of Pidotimod in Treatment of Paediatric Chronic Tonsillitis and Its Effects on Serum Interleuin-4 and Tumor Necrosis Factor-α

作　　者：张学聪[1] 杨利波[1] 

机构地区：[1]焦作市人民医院耳鼻咽喉头颈外科,河南焦作454003

出　　处：《中国医院用药评价与分析》2017年第12期1648-1649,1652,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨匹多莫德用于小儿慢性扁桃体炎的临床疗效及对患儿血清白细胞介素4(IL-4)和肿瘤坏死因子α(TNF-α)水平的影响。方法:选取2015年6月—2016年6月焦作市人民医院收治的慢性扁桃体炎患儿108例,按随机数字表法分为对照组和观察组,每组54例。对照组患儿给予常规治疗,观察组患儿在对照组基础上加用匹多莫德。比较两组患儿的复发次数、临床疗效和血清IL-4、TNF-α水平。结果:治疗期间和随访1年期间,观察组患儿复发次数明显少于对照组,差异有统计学意义(P<0.05);观察组患儿的总有效率(88.89%,48/54)明显高于对照组(66.67%,36/54),差异有统计学意义(P<0.05);治疗后,两组患儿的血清IL-4、TNF-α水平均较治疗前明显降低,且观察组患儿降低程度明显大于对照组,差异均有统计学意义(P<0.05)。结论:匹多莫德对于慢性扁桃体炎患儿具有较好的疗效,可有效降低复发次数,降低血清IL-4、TNF-α水平。OBJECTIVE ： To probe into the clinical efficacy of pidotimod in treatment of paediatric chronic tonsillitis and its effects on serum interleuin-4 （IL-4） and tumor necrosis factor-α （TNF-α）. METHODS： 108 children with chronic tonsillitis admitted into Jiaozuo People＇ s Hospital from Jun. 2015 to Jun. 2016 were selected and randomly divided into control group and observation group via random number table, with 54 cases in each group. The control group was given conventional therapy, while the observation group was treated with pidotimod based on the control group. The recurrent frequencies, clinical efficacy, levels of serum IL-4 and TNF-α. RESULTS ： During treatment and follow up in 1 year, the recurrent frequency of observation group was significantly less than that of the control group, with statistically significance difference （ P 〈 0. 05 ） ; the total effective rate of observation group （ 88.89%, 48/54） was significantly higher than that of the control group （66. 67%, 36/54）, with statistically significance difference （P 〈 0. 05） ; after treatment, levels of serum IL-4 and TNF-α of both groups had been significantly decreased, and those of the observation group were significantly lower than the control group, with statistically significance differences （P 〈 0. 05 ）. CONCLUSIONS ： The efficacy of pidotimod in treatment of paediatric chronic tonsillitis is remarkable, which can significantly reduce its recurrent frequencies, bring down the serum IL-4 and TNF-α levels.

关 键 词：匹多莫德 小儿慢性扁桃体炎 白细胞介素4 肿瘤坏死因子Α 

分 类 号：R979.5[医药卫生—药品]