戊巴比妥钠在家兔手术中的麻醉效果分析  

Study on Anesthetic Effect of Pentobarbital Sodium in Rabbit Surgery

作　　者：朱力鸣 石慧丽[2] 焦昆 钟光珍[2] 李胜利 

机构地区：[1]首都医科大学实验动物部,北京100069 [2]首都医科大学附属北京朝阳医院,北京100043

出　　处：《实验动物科学》2017年第6期55-57,60,共4页Laboratory Animal Science

摘　　要：目的探讨戊巴比妥钠在不同剂量下对家兔的麻醉时间与效果,分析其作用特点。方法 53只日本大耳白兔,采用不同的麻醉剂量标准(3%水溶液,1.1、1.3、1.4、1.6 m L/kg BW)静脉注射麻醉后,行心脏外科手术,手术完成后记录麻醉药品使用总量以及手术时长等数据,对麻醉剂量与麻醉时间的量效关系进行分析。结果随着初始麻醉剂量的增加,兔麻醉时间也呈上升趋势,但在一定剂量时即可发挥满意麻醉效果.手术时间越长,追加麻醉剂次数亦增加,麻醉事故发生率同步增加。结论时长在1 h内的实验兔手术操作,使用3%戊巴比妥钠溶液以静脉注射方式麻醉,剂量以1.3~1.4 mg/kg BW左右为佳。手术时长较长者,应配合使用局麻药或镇痛药以减少戊巴比妥钠用量,避免麻醉意外事故的出现。Objective To investigate the anesthetic time and effect of pentobarbital sodium on rabbits at different doses. Method Before the cardiac surgery, rabbits （n = 53） were anesthetized with different anesthetic standards （1.1, 1.3, 1.4, 1.6 mg/kg BW）. The total amount of narcotic drugs used and the time of the operation were recorded, and the dose effect relationship between anesthetic dose and anesthetic time was analyzed. Result With the increase of the initial anesthetic dose, the time of anesthesia in rabbits also increased, but the longer the operation time, the number of additional anesthetics also increased, and the incidence of anesthesia accidents increased simultaneously. Conclusion Surgical operation of rabbits with length of 1 hour, the most appropriate dose of 3% pentobarbital sodium solution is I. 3 - 1.4 mg/kg BW. If the time of the operation is longer, the use of local anesthetics or analgesics should be used to reduce the amount of pentobarbital sodium and avoid the occurrence of anesthesia.

关 键 词：大耳白兔 戊巴比妥钠 麻醉 

分 类 号：R965[医药卫生—药理学]