稠李提取物对急性酒精性肝损伤小鼠的保护作用  

Protective Effect of Extracts of Padus virginiana on Acute Alcoholicinduced Liver Injury

作　　者：王梓[1] 吕晓艳 李琼[1] 李艳姿 刘双利[1] 张连学[1] 刘成禹[3] 

机构地区：[1]吉林农业大学中药材学院,长春130118 [2]吉林大学白求恩第二医院检验科,长春130041 [3]长春中医药大学针炙推拿学院,长春130117

出　　处：《吉林农业大学学报》2017年第6期683-686,694,共5页Journal of Jilin Agricultural University

基　　金：国家公益性行业科研专项(201303111);吉林农业大学科研启动基金项目(2016052)

摘　　要：为探讨稠李提取物(PVE)对急性酒精性肝损伤小鼠的作用及机制。建立ICR小鼠急性酒精性肝损伤模型,通过检测小鼠血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)、甘油三酯(TG)、肝组织中丙二醛(MDA)、还原型谷胱甘肽(GSH)的含量,苏木素—伊红(H&E)染色观察肝组织病理变化,研究了稠李提取物对急性酒精性肝损伤小鼠的保护作用及作用机理。结果表明:稠李提取物能够降低ALT、AST、TG和MDA含量,提高GSH含量,并显著改善肝细胞脂肪变性、坏死。这说明稠李提取物可通过提高抗氧化能力来缓解酒精所致的急性肝损伤。The study was conducted to investigate the protective effect of the extracts of Padus virginiana（ PVE） on acute alcoholic-induced liver injury in mice and its possible mechanism. The acute alcoholic-induced liver injury model of ICR mice was established. The levels of alanine aminotransferase（ ALT）, aspartate aminotransferase（ AST）, triglyceride（ TG）, malondialdehyde（ MDA） Glutathione（ GSH） and hematoxylin-eosin（ HE） staining were used to observe the pathological changes. The results show that PVE could reduce the content of ALT,AST,TG and MDA,increase the content of GSH,and obviously improve the fatty degeneration and necrosis of liver cells,indicating that PVE can reduce the acute alcoholic-induced liver injury by increasing the antioxidant capacity.

关 键 词：稠李 酒精性肝损伤 氧化应激 小鼠 

分 类 号：R285.5[医药卫生—中药学] S567.1[医药卫生—中医学]