Three new anthraquinone derivatives isolated from Symplocos racemosa and their antibiofilm activity  

作　　者：Umar Farooq Sara Khan Sadia Naz Ajmal Khan Afsar Khan Ayaz Ahmed Abdur Rauf Syed Majid Bukhari Shujaat Ali Khan Arfa Kamil Nadia Riaz Abdur Rahman Khan 

机构地区：[1]Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan [2]Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi- 752 70, Pakistan [3]Department of Geology, University of Swabi Anbar-23430, KPK, Pakistan [4]Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan [5]Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Federal Urdu University of Arts, Science and Technology, Karachi, Karachi 75300, Pakistan [6]Department of Environmental Sciences, COMSATS Institute of lnformation Technology, Abbottabad-22060, Pakistan

出　　处：《Chinese Journal of Natural Medicines》2017年第12期944-949,共6页中国天然药物（英文版）

基　　金：supported by Higher Education Commission(HEC)of Pakistan for financial support under NRPU programme(No.20-2003/NRPU);COMSATS Abbottabad for financial support

摘　　要：Three new alkyl substituted anthraquinone derivatives, trivially named as symploquinones A-C(Compounds 1-3) were isolated from Symplocos racemosa. The structures of these compounds were determined on the basis of extensive spectroscopic analyses(UV, IR, Mass, ~1 H-and ^(13)C-NMR, and two-dimensional(2D) NMR techniques). The resulting data were also compared with the reported literature. These compounds were then subjected to antibacterial or antibiofilm testing. Compounds 1 and 3 exhibited good antibacterial activity in the concentration range of 160-83 μg·m L^(-1) against Streptococcus mutans, methicillin resistant Staphylococcus aureus and Proteus mirabilis. Both compounds were further screened for anti-biofilm activity, which revealed promising activities at sub-MIC concentrations. None of the compounds were found to be active against Klebsiella pneumoniae.Three new alkyl substituted anthraquinone derivatives, trivially named as symploquinones A-C（Compounds 1-3） were isolated from Symplocos racemosa. The structures of these compounds were determined on the basis of extensive spectroscopic analyses（UV, IR, Mass, ^1 H-and ^13C-NMR, and two-dimensional（2D） NMR techniques）. The resulting data were also compared with the reported literature. These compounds were then subjected to antibacterial or antibiofilm testing. Compounds 1 and 3 exhibited good antibacterial activity in the concentration range of 160-83 μg·mL^-1 against Streptococcus mutans, methicillin resistant Staphylococcus aureus and Proteus mirabilis. Both compounds were further screened for anti-biofilm activity, which revealed promising activities at sub-MIC concentrations. None of the compounds were found to be active against Klebsiella pneumoniae.

关 键 词：SYMPLOCOS racemosa SUBSTITUTED ANTHRAQUINONE ANTIBIOFILM activity 

分 类 号：R284.1[医药卫生—中药学] R965[医药卫生—中医学]