α受体及M受体阻滞剂联合应用治疗留置双J管致下尿路症状的效果分析  

Evaluation of combination therapy with α and M receptors antagonist for the treatment of double J stents related lower urinary tract symptoms

作　　者：姜涛[1] 王永辉[2] 高军[3] 

机构地区：[1]抚顺矿务局总医院药剂科,113008 [2]抚顺矿务局总医院泌尿外科,113008 [3]沈阳军区总医院泌尿外科

出　　处：《中国综合临床》2017年第11期1018-1021,共4页Clinical Medicine of China

摘　　要：目的 分析留置双J管所致下尿路症状（LUTS）患者联合α受体阻滞剂与M受体阻滞剂的治疗效果.方法 选择2013年1月至2016年12月接受泌尿外科手术术后留置双J管120例患者,以随机数字表法均分成对照组（未给予任何药物干预,30例）、治疗A组（口服坦索罗辛0.2 mg,30例）、治疗B组（口服索利那新5.0 mg,30例）、联合组（联合坦索罗辛0.2 mg＋索利那新5.0 mg,30例）,后3组服药均为1次/d.记录术前、术后1、4周各组患者的国际前列腺症状评分（IPSS）、生命质量评分（QOL）和可视疼痛量表评分（VAPS）并进行统计学比较.结果 联合组术后4周IPSS总评分[（8.21±2.36）分]、对照组[（13.68±3.65）分]、治疗A组[（12.59±3.76）分]、治疗B组[（12.39±4.58）分]比较差异有统计学意义（F组间=7.905,P〈0.05）,且术后4周联合组 IPSS 总评分均较其他3组显著降低（P 均〈0.05）;联合组术后4周 QOL 评分[（1.52 ± 0.99）分]、对照组[（2.86 ± 1.14）分]、治疗 A 组[（2.69 ±1.21）分]、治疗B组[（2.74±1.40）分],比较差异有统计学意义（F组间=13.725,P〈0.05）,且术后4周联合组QOL评分均较其他3组显著降低（P均〈0.05）.各组间VAPS评分比较差异均无统计学意义（P均〉0.05）.结论 泌尿系手术后留置双J管所致LUTS患者联合给予α受体阻滞剂与M受体阻滞剂可明显改善相关症状.Objective To evaluate the efficacy of combination therapy with α and M receptors antagonist for the treatment of double J stents related lower urinary tract symptoms.Methods From January 2013 to December 2016,one hundred and twenty patients were accepted the doubte J stents indwelling after the ureteral lithotripsy,laparoseopie ureterlithotomy and pyeloureteroplasty.They were divided into four groups randomly,including control group（30 cases,no drugs were taken）,tamsulosin group（30 cases,0.2 mg tamsulosin was taken qd）,solifenacin group（30 cases,5 mg solifenacin was taken qd）,combination group（30 cases,0.2 mg tamsulosin and 5 mg solifenacin were taken qd）.The IPSS scores,QOL scores and visual analogue pain scale（VAPS）scores were assessed pre-operation,1 week after operation,and 4 weeks after operation, respectively.Results The total IPSS scores in the combination group 4 weeks after operation was（8.21±2.36） points,compared with the control group（（13.68 ± 3.65）points）,the tamsulosin group（（12.59 ± 3.76） points）,the solifenacin group（（12.39 ±4.58）points）,the difference was statistically significantly lower（F=7.905,P〈0.05）.And 4 weeks after operation,the QOL scores in the combination group（（1.52±0.99）points） was significantly lower than that in the control group（（2.86±1.14）points）,the tamsulosin group（（2.69± 1.21）points）and the solifenacin group（（2.74 ± 1.40）points）（F=13.725,P〈0.05）.While the VAPS scores didn′t show significant differences among those groups（P〉0.05）.Conclusion α and M receptors antagonist combination therapy can significantly improve lower urinary tract symptom due to indwelling double J stents.

关 键 词：双J管 下尿路症状 索利那新 坦索罗辛 

分 类 号：R699[医药卫生—泌尿科学]