瑞舒伐他汀对急性冠脉综合征合并心律失常患者炎性因子变化的影响  

Influence of rosuvastatin on inflammatory factors in patients with acute coronary syndrome complicated by arrhythmia

作　　者：杜建青[1] 张代富[1] 

机构地区：[1]上海市浦东新区人民医院心内科,上海201200

出　　处：《中国循证心血管医学杂志》2017年第12期1458-1460,1463,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：上海市卫生计划委员会青年基金(20144Y0154)

摘　　要：目的探讨瑞舒伐他汀对急性冠脉综合征(ACS)合并心律失常患者炎症和凋亡反应的作用。方法选择2011年5月~2015年5月于上海市浦东新区人民医院心内科确诊的50例单纯性ACS患者(单纯性ACS组)与50例ACS合并心律失常患者(ACS合并心律失常组)为研究对象,两组患者均于每晚睡前服用10 mg瑞舒伐他汀治疗。对两组治疗前后血脂指标、谷草转氨酶(AST)、谷丙转氨酶(ALT)、同工酶(CK)、血浆v WF(%),治疗前后炎症因子,包括脂肪酸合成酶(FASN)、白介素-1β(IL-1β)、高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白介素-18(IL-18)进行比较,并对ACS合并心律失常组治疗前后室性早搏Lown分级与炎症因子的相关性进行分析。结果除LDL-C外,两组治疗前后其他血脂指标、AST、ALT、CK、血浆v WF水平相比,差异均有统计学意义(P<0.05);ACS合并心律失常组治疗前各炎症因子水平均显著高于单纯ACS组治疗前各炎症因子水平(P<0.05),且两组治疗前后炎症因子水平差异均具有统计学意义(P<0.05);ACS合并心律失常组患者治疗前后炎症因子水平随着室性早搏Lown分级的递增而升高。结论 ACS合并心律失常与炎症因子存在正相关,说明炎症因子可能是ACS并发心律失常的重要原因;瑞舒伐他汀具有抗炎及抗凋亡作用,治疗ACS合并心律失常效果显著,值得临床推广应用。Objective To discuss the effect of rosuvastatin on inflammatory factors and apoptosis response in patients with acute coronary syndrome （ACS） complicated by arrhythmia. Methods The patients with simple ACS （n=50, ACS group） and patients with ACS complicated by arrhythmia （n=50, ACS＋arrhythmia group） were chosen from the People’s Hospital of Pudong New District in Shanghai City from May 2011 to May 2015, and treated orally with rosuvastatin （10 mg） every night before bed. The indexes of blood fat, aspertate aminotransferase （AST）, alanine aminotransferase （ALT）, creatine kinase-MB isoenzyme （CK-MB）, plasma von Willebrand factor （vWF, %）, and inflammatory factors including fatty acid synthase （FAS）, interleukin-1β （IL-1β）, high-sensitivity C-reactive protein （hs-CRP）, tumor necrosis factor-α （TNF-α） and interleukin-18 （IL-18） were compared in 2 groups before and after treatment. The correlation between Lown grading of premature ventricular contraction （PVC） and inflammatory factors was analyzed in ACS＋arrhythmia group before and after treatment. Results The difference in indexes of blood fat （except of LDL-C）, AST, ALT, CK-MB and plasma vWF had statistical significance between 2 groups before and after treatment （P〈0.05）. The levels of all inflammatory factors were significantly higher in ACS＋arrhythmia group than those in ACS group before treatment （P〈0.05）, and difference in levels of inflammatory factors had statistical significance in 2 groups before and after treatment （P〈0.05）. The levels of inflammatory factors increased along with Lown grading of PVC increased progressively in ACS＋arrhythmia group before and after treatment. Conclusion ACS complicated by arrhythmia is positively correlated to inflammatory factors, which indicates that inflammatory factors are important cause of ACS complicated by arrhythmia. Rosuvastatin has the effects of anti-inflammation and anti-apoptosis with significant efficacy in

关 键 词：瑞舒伐他汀 ACS合并心律失常 炎症因子 凋亡反应 室性早搏Lown分级 

分 类 号：R541.4[医药卫生—心血管疾病]