老年急性ST段抬高型心肌梗死RyR2及UCP2蛋白治疗前后水平变化研究  

Changes of ryanodine receptor 2 and uncoupling protein 2 in elderly patients with acute ST-segment elevation myocardial infarction

作　　者：王娟丽 张利 高晓梅 

机构地区：[1]陕西省周至县人民医院内二科,周至710400

出　　处：《中国循证心血管医学杂志》2017年第12期1492-1494,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探讨老年急性ST段抬高型心肌梗死兰尼碱受体2(Ry R2)及解偶联蛋白2(UCP2)蛋白在治疗前后的水平变化,为临床诊断及治疗提供参考。方法纳入陕西省周至县人民医院2011年1月~2016年12月间诊治的老年急性心肌梗死患者120例,其中ST段抬高型心肌梗死64例(STEMI组)、非ST段抬高型心肌梗死患者56例(NSTEMI组),同期入选健康体检者60例作为对照组,比较分析各组Ry R2、UCP2及心肌肌浆网Ca2+-ATP酶2a(s SERCA2a)、沉默信息调节因子1(SIRT1)蛋白水平变化。结果老年急性心肌梗死患者Ry R2、SERCA2a、UCP2及SIRT1蛋白水平明显低于对照组(P<0.05),且ST段抬高型心肌梗死患者的上述蛋白表达水平明显低于非ST段抬高型心肌梗死患者(P<0.05);ST段抬高型心肌梗死患者经溶栓、抗栓治疗后上述蛋白的表达明显升高,且明显高于治疗前(P<0.05),但上述蛋白水平仍明显低于对照组(P<0.05)。结论 Ry R2及UCP2蛋白对老年急性ST段抬高型心肌梗死的临床诊断有一定价值。Objective To investigate the changes of levels of ryanodine receptor 2 （RyR2） and uncoupling protein 2 （UCP2） in elderly patients with acute ST-segment elevation myocardial infarction （STEMI） before and after treatment, and provide reference for clinical diagnosis and treatment. Methods The elderly patient with acute myocardial infarction （n=120） were chosen from Jan. 2011 to Dec. 2016, and divided into STEMI group （n=64） and non-STEMI group （n=56, NSTEMI group）. At the same time health controls （n=60） were chosen into control group. The changes of levels of RyR2, UCP2, sarcoplasmic reticulum Ca2＋-ATPase2a （SERCA2a） and silent information regulator 1 （SIRT1） were compared and analyzed in all groups. Results The levels of RyR2, SERCA2a, UCP2 and SIRT1 all were significantly lower in STEMI group and NSTEMI group than those in control group （P〈0.05）, and were lower in STEMI group than those in NSTEMI group （P〈0.05）. After thrombolytic and antithrombotic treatment, the levels of RyR2, SERCA2a, UCP2 and SIRT1 increased significantly in STEMI group and NSTEMI group （P〈0.05）, but were still lower significantly than those in control group （P〈0.05）. Conclusion RyR2 and UCP2 have some diagnostic value to senile STEMI in clinical practice.

关 键 词：心肌梗死 兰尼碱受体2 心肌肌浆网Ca2+-ATP酶 抗栓治疗 

分 类 号：R542.22[医药卫生—心血管疾病]