Non-equilibrium and stochasticity influence the activation process of the yeast DNA damage pathway  

作　　者：ChenZi Jin XiaoDong Yan FangTing Li 

机构地区：[1]School of Physics, Center for Quantitative Biology, Peking University

出　　处：《Science China(Physics,Mechanics & Astronomy)》2018年第2期76-79,共4页中国科学：物理学、力学、天文学（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.11174011,and 91130005);the National Key Basic Research Project of China(Grant No.2015CB910300)

摘　　要：Living cells are open systems that exist far away from a state of thermodynamical equilibrium. They utilize the high-grade chemical energy provided by food to produce ATP and re- lease ADP and Pi together with heat dissipation. Living cells exist in a non-equilibrium steady state （NESS）, they replicate themselves and respond to various environmental changes via signal transduction pathways. Because the majority of cells exist at room temperature, the stochasticity of chemical reac- tions in the cells is unavoidable. Recent research into fluores- cent proteins and microscopy techniques have enabled us to observe the dynamic process of mRNA and proteins in single living bacterial cells [1], and these have resulted in new in- sights into regulation mechanisms in molecular biology, i.e., in cellular signal transduction pathways.Living cells are open systems that exist far away from a state of thermodynamical equilibrium.They utilize the high-grade chemical energy provided by food to produce ATP and release ADP and Pi together with heat dissipation.Living cells exist in a non-equilibrium steady state(NESS),they replicate themselves and respond to various environmental changes

关 键 词：NON-EQUILIBRIUM stochasticity influence DNA damage pathway 

分 类 号：N0[自然科学总论—科学技术哲学]