上海市嘉定区2012-2015年妊娠合并梅毒与早产、低出生体质量发生的相关性研究  

Study on the correlations between syphilis during pregnancy and premature birth and low birth weight in Jiading District,Shanghai from 2012 to 2015

作　　者：邓晓 李生慧[1] 毛红芳[2] 王海琪[2] 王海鸣[2] 曹敏[2] 

机构地区：[1]上海交通大学公共卫生学院,上海200025 [2]上海市嘉定区妇幼保健院,上海201812

出　　处：《中国妇幼保健》2018年第1期159-162,共4页Maternal and Child Health Care of China

基　　金：国家自然科学基金面上项目(81673183);上海市公共卫生优秀学科带头人培养计划(GWDTR201222)

摘　　要：目的了解上海市嘉定区妊娠合并梅毒的流行情况,探讨妊娠合并梅毒早产、低出生体质量儿发生情况及影响因素。方法回顾性分析嘉定区2012-2015年筛查出的妊娠合并梅毒个案共266例,利用同期嘉定区预防梅毒母婴传播信息系统月报表及相关产科报表等信息登记,随机选取非梅毒孕产妇266例,开展病例对照研究,应用SPSS统计软件进行数据分析。结果2012-2015年孕产妇产时梅毒检出率由0.66%上升至2.30%,呈现逐年上升趋势(χ~2=6.229,P=0.013)。与非梅毒孕产妇相比,妊娠合并梅毒者早产发生率(7.52%vs.3.02%)、低出生体质量儿发生率(6.64%vs.2.26%)均显著上升,差异具有统计学意义(P<0.05)。妊娠合并梅毒者早产发生率:甲苯胺红不加热血清试验(TRUST)≥1:8组(11.63%)大于TRUST<1:8组(8.06%);未用药组(19.05%)>不规范用药组(7.87%)>规范用药组(0)。妊娠合并梅毒者低出生体质量儿发生率:TRUST≥1:8组(11.63%)大于TRUST<1:8组(5.65%);未用药组(14.29%)>不规范用药(7.87%)>规范用药组(0)。结论妊娠合并梅毒可导致早产、低出生体质量儿发生率的增加,妊娠合并梅毒患者早产、低出生体质量儿的发生与梅毒血清学滴度及孕期是否规范用药密切相关,孕期规范用药能明显降低妊娠合并梅毒患者早产、低出生体质量儿的发生率。Objective To investigate the prevalence of syphilis during pregnancy in Jiading District,Shanghai,explore the occurrence and influencing factors of premature birth and low birth weight in patients with syphilis during pregnancy. Methods A total of 266 patients with syphilis during pregnancy screened in Jiading District from 2012 to 2015 were analyzed retrospectively. Based on mother-to-child syphilis transmission registration system in Jiading District from 2012 to 2015,266 pregnant women without syphilis were randomly selected as control group,a case-control study was conductd,SPSS software was used for data analysis. Results From 2012 to 2015,the detection rate of maternal intrapartum syphilis rose from 0. 66% to 2. 30%,showing an increasing trend year by year（ χ~2= 6. 229,P = 0. 013）. Compared with pregnant women without syphilis,the incidence rates of preterm birth and low birth weight infants in pregnant women with syphilis increased significantly（ 7. 52% vs. 3. 02%,6. 64% vs. 2. 26%）（ P0. 05）. Among the pregnant women with syphilis,the incidence rate of preterm birth in toluidine red unheated serum test（ TRUST） ≥1 ： 8 group was 11. 63%,which was higher than that in TRUST 1 ： 8 group（ 8. 06%）,the incidence rate of preterm birth in non-drug treatment group was 19. 05%,which was higher than that in irregular drug treatment group（ 7. 87%）,and the incidence rate of preterm birth in irregular drug treatment group was higher than that in regular drug treatment group（ 0. 00%）. Among the pregnant women with syphilis,the incidence rate of low birth weight infants in TRUST≥1 ： 8 group was 11. 63%,which was higher than that in TRUST1 ： 8 group（ 5. 65%）,the incidence rate of low birth weight infants in non-drug treatment group was 14. 29%,which was higher than that in irregular drug treatment group（ 7. 87%,and the incidence rate of low birth weight infants in irregular drug treatment group was higher than that in regular drug treatment group（ 0. 00%）. Conclusion Syphili

关 键 词：妊娠合并梅毒 早产 低出生体质量儿 

分 类 号：R714[医药卫生—妇产科学]