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作 者:王一[1] 赵彤[2] 凌云[1] 张曦[1] 周春祥[1,3]
机构地区:[1]南京中医药大学基础医学院,江苏南京210046 [2]第二军医大学附属长海医院中医科,上海200433 [3]南京中医药大学明基教学医院,江苏南京210036
出 处:《辽宁中医杂志》2017年第12期2578-2580,共3页Liaoning Journal of Traditional Chinese Medicine
基 金:国家自然科学基金(81503485);南京市科技计划项目(201402054)
摘 要:目的:通过益气养血化瘀解毒法联合西医常规治疗,寻找更加科学有效的联合治疗手段,改善患者的急性期症状,降低放射性肺炎的发生率,并探究其可能的作用机制。方法:40例患者采用随机数字表法随机分为治疗组和对照组各20例,对照组采用西医常规治疗,激素泼尼松联合抗生素头孢呋辛,治疗组在对照组的基础上加用以益气养血化瘀解毒为法的中药汤剂口服。两组均在出现放射性肺炎症状时开始治疗,共观察6周。各组于治疗前后分别观察症状缓解效果、TGF-β1水平以及不良反应的发生情况,评价临床疗效。结果:与对照组比较,治疗组在干咳、气喘、呼吸困难这3个症状的改善显著,缓解率更高(P<0.05);治疗组在治疗后TGF-β1水平明显低于对照组(P<0.05);与对照组相比,治疗组的不良反应发生率更低(P<0.05)。结论:益气养血化瘀解毒法联合常规西医治疗相比单纯的西医常规方式治疗放射性肺炎,在主要临床症状的缓解上有一定的优势,且不良反应发生率小,安全性高,其机制可能是通过对TGF-β1水平的抑制。Objective :Through Yiqiyangxue Huayujiedu method and western medicine treatment, to look for more scientific and effective treatment to improve the patients' acute phase symptoms and reduce the incidence of radiation pneumonitis. Methods: Forty patients were randomly divided into treatment group and control group,20 cases in each. The control group received routine treatment,hormone prednisone combined with antibiotics cefuroxime. On the basis of the control group, the treatment group was treated with Chinese herbal medicine. The two groups were treated with radiation pneumonitis, and we observed for 6 weeks. In each group,we observed before and after treatment alleviating symptoms effect, TGF - 61 level and the incidence of adverse reac- tions. Results : Compared to the control group, treatment group was significant in the improvement of the symptoms of cough, wheez- ing, difficulty breathing and the relieve rate was higher, and the difference was statistically significant (P 〈 0. 05 ). In the treatment group, the level of TGF - 151 after treatment was significantly lower than that of the control group, and the difference was statisti- caUy significant (P 〈 0. 05 ). Compared with the control group, the incidence of adverse reactions in the treatment group was low- er, and the difference was statistically significant ( P 〈 0. 05 ). Conclusion : Compared with simple western medicine routine treat- ment, Yiqiyangxue Huayujiedu method and western medicine treatment has certain advantages in the main clinical symptoms and the inhibitory effect on the expression of TGF- 61 and the incidence of adverse reactions is small, and the safety is high.
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