论痛性糖尿病周围神经病变相关电压门控离子通道  

Discussion of Voltage-gated Ion Channels Associated with Painful Diabetic Peripheral Neuropathy

作　　者：唐春颖 冷锦红 

机构地区：[1]辽宁中医药大学附属医院

出　　处：《辽宁中医药大学学报》2018年第1期157-161,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：辽宁省科技厅科学技术计划项目(2013226012);沈阳市科技攻关项目(F13-221-9-55)

摘　　要：痛性糖尿病周围神经病变（PDPN）的典型临床表现以肢体对称性的麻木疼痛、灼热或冰凉、感觉减退、夜间尤甚为主,是困扰糖尿病周围神经病变患者的主要因素,约有25%的糖尿病患者存在痛性糖尿病周围神经病变。近年随着离子通道学说的发展,其在糖尿病周围神经病变发病机制中也占据了一席之地。与PDPN关系密切、研究较多的电压门控离子通道主要有Na^＋通道、K^＋通道、Ca^2＋通道,该文将阐述与痛性糖尿病周围神经病变关系密切的离子通道,及与其的相关性。It is the typical symptoms of painful diabetic peripheral neuropathy which is the numbness and pain,scorching or cold,hypaesthesia of limb symmetry,especially at night. It is a major factor that affects diabetic peripheral neuropathy. It is about 25% of diabetic patients which suffer from painful diabetic peripheral neuropathy. With the development of ion channel theory,it also occupies a place in the pathogenesis of diabetic peripheral neuropathy in recent years. Voltage-gated ion channels mainly include Na^＋ channels,K^＋ channels,and Ca^2＋ channels which closely related to PDPN. This article will describe the ion channels that are closely related to PDPN,and reveal their correlation.

关 键 词：痛性糖尿病周围神经病变 电压门控离子通道 相关性 

分 类 号：R587.1[医药卫生—内分泌]