镇静催眠药物治疗抑郁症共病失眠的研究现状  

Current situation of sedative-hypnotic drugs in the treatment of patients with comorbided depression and insomnia

作　　者：王占璋[1] 尚德为[1] 倪晓佳[1] 卢浩扬[1] 张明[1] 温预关[1] 

机构地区：[1]广州医科大学附属脑科医院广州市惠爱医院药学部,广州510370

出　　处：《中国临床药理学杂志》2018年第1期77-80,84,共5页The Chinese Journal of Clinical Pharmacology

基　　金：广州市科技计划基金资助项目(2014 J4100135);广州市医药卫生科技一般引导基金资助项目(20161 A011037);广州市医学重点专科基金资助项目

摘　　要：失眠和抑郁症是临床上常见的精神障碍,二者可能呈双向病程关系。急慢性失眠首先推荐认知行为治疗,如认知行为治疗无效或伴有精神症状时,可以单用或合用抗抑郁药、苯二氮或非苯二氮类镇静催眠药、非典型抗精神病药进行治疗。本文就现有抑郁症共病失眠患者的临床研究作一综述,为镇静催眠药物的选择提供参考。Insomnia and depression are common mental disorders and there exists bidirectionality between sleep symptoms and depressive symptoms. Cognitive behavioral therapy for insomnia（ CBT-I） is recommanded first in patients with accute or chronic insomnia. Pharmacotherapy treatment is recommended when CBT-I is insufficient or patients are comorbided with depression or other mental diseases. Pharmacotherapy treatment options include antidepressants,benzodiazepines,non-benzodiazepines,atypical antipsychotics as monotherapy or cotherapy. The aim of the present review was to discuss the selection and clinical application of sedative-hypnotic drugs in patients with comorbid depression and insomnia.

关 键 词：抑郁 失眠 镇静催眠药物 

分 类 号：R971.3[医药卫生—药品]