还少胶囊联合左卡尼汀治疗少、弱、畸精子症的疗效观察  

Huanshao Capsules combined with levocarnitine for the treatment of asthenospermia,oligospermia and teratozoospermia

作　　者：张鹤云[1] 李健[1] 赵云[2] 张宏景 毕晓方[1] 王春晖[1] 杨洋[1] 熊杰[1] 史云强[1] 钟一鸣[1] 张春和[3] 

机构地区：[1]昆明医科大学附属延安医院泌尿外科,云南昆明650051 [2]昆明医科大学第二临床学院临床医学专业,云南昆明650500 [3]云南省中医医院泌尿男科,云南昆明650021

出　　处：《中华男科学杂志》2018年第1期67-71,共5页National Journal of Andrology

摘　　要：目的:观察还少胶囊及其联合左卡尼汀口服液治疗少、弱、畸精子症的临床疗效及对精子参数的影响。方法:采用随机对照的临床研究,将确诊的186例脾肾虚损型男性不育患者患者随机分为治疗组、对照组和联合治疗组,每组62例。治疗组给予还少胶囊治疗,每日3次,每次3粒;对照组给予左卡尼汀口服液治疗,每日3次,每次1支(10 ml);联合用药组给予还少胶囊联合左卡尼汀口服液治疗,用法同上。3组均用药12周,随访3次,治疗后第4周、第8周、第12周分别检测两组精液质量(精液量、精子浓度、精子活率、前向运动精子百分率)及精子畸形率。结果:180例患者完成了临床研究,治疗12周后,联合用药组精液量提高42.77%,精子浓度提高142.37%,精子活动率增加28.61%,前向运动精子百分率增加24.39%,精子畸形率下降6.27%,与用药前相比都有显著提高,差异有统计学意义(P<0.05)。联合用药组在提高精液量、精子浓度、精子活率、前向运动精子百分率上优于对照组(P<0.05),在提高精子活率、前向运动精子百分率上优于治疗组(P<0.05)。治疗组用药后精液量、精子浓度、精子活率、前向运动精子百分率、精子畸形率与用药前相比都有显著提高,差异有统计学意义(P<0.05),治疗组在提高精液量和精子浓度上显著优于对照组(P<0.05)。结论:还少胶囊联合左卡尼汀治疗少、弱、畸形精子症安全有效,值得临床推广。Objective： To observe the clinical effects of Huanshao Capsules （HSC） combined with levocarnitine （LC） on as- thenospermia, oligospermia, teratozoospermia, and the semen parameters of the patients. Methods ： This randomized controlled clinical study included 186 infertility patients with spleen and kidney asthenia. We randomly divided them into three groups of equal num- ber and treated them orally with HSC at the dose of 3 capsules tid, LC at 10 ml tid, and HSC ＋ LC, respectively, all for 12 weeks. At 4, 8, and 12 weeks after treatment, we obtained the semen parameters from the patients and compared them among the three groups. Results： Totally, 180 of the patients completed the study, 61 in the HSC, 59 in the LC and 60 in the HSC ＋ LC group. After 12 weeks of medication, the patients of the HSC ＋ LC group showed an increase of 42.77% in the semen volume, 142.37% in sperm concentra- tion, 28.61% in sperm motility, and 24.39% in the percentage of grade a ＋ b sperm and a decrease of 6.27% in the percentage of morphologically abnormal sperm as compared with the baseline （ P 〈 0.05 ）. The patients treated with HSC ＋ LC showed significantly more improvement in all the above parameters than those treated with LC alone （P 〈 0.05） as well as in sperm motility and the percentage of progressively motile sperm than those treated with HSC alone （P 〈 0.05 ）. The HSC group exhibited remarkable improvement in the above parameters after treatment as compared with the baseline （ P 〈 0.05 ） and higher semen volume and sperm concen- tration than the LC group （ P 〈 0. 05 ）. Conclusion ： Huanshao Capsulescombined with levocarnitinedeserves a wide clinical application as a safe and efficacious therapy forasthenospermia, oligospermia, and teratozoospermia.

关 键 词：少精子症 弱精子症 畸形精子症 还少胶囊 左卡尼汀口服液 疗效 

分 类 号：R698.2[医药卫生—泌尿科学]