乌司他丁静脉滴注在治疗儿童重症肺炎中的效果评价  

Effect evaluation of Ulinastatin intravenous drip in the treatment of severe pneumonia in children

作　　者：戴上康[1] 余洽超[1] 谭永红[1] 

机构地区：[1]广东省开平市中心医院儿科,广东开平529300

出　　处：《中国当代医药》2018年第1期129-131,共3页China Modern Medicine

摘　　要：目的探讨乌司他丁静脉滴注在治疗儿童重症肺炎中的临床效果。方法选取2013年2月~2016年12月我院收治的60例儿童重症肺炎患者作为研究对象,按照随机数字法将其平均分为对照组和研究组,每组30例。对照组患者予以常规治疗,研究组患者予以乌司他丁治疗。比较两组患者的体温恢复正常时间、白细胞计数恢复正常时间、住院时间、急性生理与慢性健康评分(APACHE-Ⅱ)、肺功能相关指标以及炎性应激状态相关指标水平。结果研究组患者的体温恢复正常时间、白细胞计数恢复正常时间、住院时间均显著短于对照组,差异有统计学意义(P<0.05),APACHE-Ⅱ评分显著低于对照组,差异有统计学意义(P<0.05)。干预后,研究组患者的PO_2、PaO_2/FiO_2、肺适应性均高于对照组,P(A-a)O_2、呼吸频率均低于对照组,差异均有统计学意义(P<0.05)。干预后,两组患者的IL-1β、TNF-α、CRP、IL-8、PCT水平均显著低于本组干预前,且研究组患者的各指标均显著低于对照组,差异有统计学意义(P<0.05)。结论乌司他丁静脉滴注在治疗儿童重症肺炎中可显著缓解炎症反应,改善肺功能,临床疗效确切。Objective To investigate the clinical effect of Ulinastatin intravenous drip in the treatment of severe pneu- monia in children.Methods 60 children with severe pneumonia treated in our hospital from February 2013 to December 2016 were selected as subjects and divided into control group and study group according to random number method, each group had 30 cases.The patients in the control group received routine treatment,and the patients in the study group were treated with Ulinastatin.The body temperature returned to normal time,white blood cell （WBC） count recov- ery time,hospitalization time,acute physiology and chronic health evaluation （APACHE- II） and related indexes of lung function and inflammatory stress related indexes of patients in the two groups were compared.Results The body temper- ature returned to normal time,the WBC count returned to normal time and hospitalization time of patients in the study group were significantly shorter than those in the control group,and the differences were statistically significant （P〈 0.05）.The score of APACHE- II of patients in the study group was lower than that of control group,and the difference was statistically significant （P〈0.05）.After intervention,the PO2,PaOJFiO2 and lung adaptability of the study group were higher than those in the control group,and P（A-a）O2 and respiration rate were lower than those in the control group,and the differences were statistically significant （P〈0.05）.After intervention,two groups of patients of IL-1β,TNF-α,CRP,IL- 8,PCT levels were significantly lower than before intervention,and the above indices of patients in the study group were significantly lower than the control group,the differences were statistically significant （P〈0.05）.Conclusion Ulinastatin intravenous drip can significantly alleviate inflammatory reaction and improve lung function in the treatment of severe pneumonia in children,and has definite clinical efficacy.

关 键 词：乌司他丁 重症肺炎 儿童 呼吸功能 

分 类 号：R725.6[医药卫生—儿科]