人参皂苷Rg1在肝脏疾病中的药理作用研究进展  

Advances in study of pharmacological effects of ginsenoside Rg1 in hepatic diseases

作　　者：罗飘[1,2] 楚世峰 高岩[2] 罗林明 彭兰 陈乃宏[1,2] 

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]中国医学科学院神经科学中心,北京协和医学院药物研究所,天然药物活性物质与功能国家重点实验室,北京100050

出　　处：《药学学报》2018年第1期21-27,共7页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81603315,U1402221,81373997,81573640); 湖南省教育厅高校科研经费开放基金项目(15K091); 新药作用机制研究与药效评价北京市重点实验室资助项目(BZ0150)

摘　　要：人参皂苷Rg1是人参主要的活性成分之一,具有抗炎、抗氧化、抗衰老、抗肿瘤和抗凋亡等广谱的药理活性。人参皂苷Rg1在机体多个组织器官系统中发挥保护作用,这表明人参皂苷Rg1的药理作用具有多靶向性。最近多项研究显示,人参皂苷Rg1具有显著的护肝作用,可能是因其具有多种药理效应。无论是在化学性肝损伤模型,还是在其他肝损伤模型中人参皂苷Rg1均可减轻因氧化应激和炎症等诱导的肝组织坏死。本文主要针对人参皂苷Rg1在各种肝损伤模型中的护肝作用及分子机制的最新研究报道进行综述。Ginsenoside Rg1 is one of the main active components of ginseng with various pharmacological activities including anti-inflammatory, anti-oxidation, anti-aging, anti-tumor and anti-apoptosis. Ginsenoside Rg1 plays a protective role in multiple tissues and organs, which shows the multiple targeting properties of the pharmacological effects. Recently, a number of studies have demonstrated that ginsenoside Rg1 has a protective role in the liver due to its multiple pharmacological effects. In chemical liver injury models, or in other liver injury models, ginsenoside Rg1 can alleviate liver necrosis induced by oxidative stress and inflammation. This article provides a review of the recent studies on the efficacy of ginsenoside Rg1 in the treatment of various liver damage and the molecular mechanism.

关 键 词：肝损伤 人参皂苷RG1 氧化应激 抗炎 抗凋亡 

分 类 号：R966[医药卫生—药理学]