联苯骨架手性双咪唑啉配体的合成及在不对称环丙烷化中的应用（英文）  

Synthesis of Chiral Bis(imidazoline) Ligands with Biphenyl Backbone and Their Application in the Asymmetric Cyclopropanation Reaction

作　　者：朱新举 牛俊龙[1] 赵雪梅[1] 郝新奇[1] 宋毛平[1] 

机构地区：[1]郑州大学化学与分子工程学院,郑州450001

出　　处：《有机化学》2018年第1期118-123,共6页Chinese Journal of Organic Chemistry

基　　金：supported by the National Natural Science Foundation of China(Nos.21528201,21672192);the China Postdoctoral Science Foundation(No.2016M602254)~~

摘　　要：一系列含有轴手性和中心手性的联苯双咪唑啉配体被首次合成.相较于传统的策略,Ullmann偶联方法表现出更高的反应效率,尤其对于含有叔丁基的配体.得到的配体被进一步应用于在铜催化下的不对称环丙烷化.A serial of biphenyl bisimidazolines containing both axial and central chirality have been synthesized for the first time. Compared with common method, Ullmann coupling methodology exhibited superior performance expecially for t-Bu substituted ligands. The obtained ligands were further applied in the Cu-catalyzed asymmetric cyclopropanation.

关 键 词：咪唑啉 轴手性 中心手性 不对称环丙烷化 

分 类 号：O621.251[理学—有机化学] O641.4[理学—化学]