从κ-阿片受体信号转导系统探讨针刺改善心肌顿抑机制研究的新思路  

New thoughts in mechanism research of acupuncture for myocardial stunning from κ-opioid receptor signaling pathway

作　　者：王圆圆[1] 刘群 陆凤燕[1] 辛娟娟[1] 戴求福 伍舒扬 赵玉雪[1] 高俊虹[1] 喻晓春[1] 

机构地区：[1]中国中医科学院针灸研究所,北京100700

出　　处：《中国针灸》2018年第1期77-81,共5页Chinese Acupuncture & Moxibustion

基　　金：国家自然科学基金项目:81674089;81774439

摘　　要：通过梳理回顾心肌顿抑的发生发展机制和针刺改善心肌缺血性损伤以及针刺与κ阿片受体的相关性研究现状,提示针刺极有可能作用于心肌细胞κ阿片受体系统,再经κ阿片受体及其受体后信号转导通路,直接参与改善心肌顿抑引发的心肌功能障碍,同时也可抑制心肌上主要功能受体——β1肾上腺素能受体信号转导通路,间接参与介导改善缺血性心肌损害的作用。笔者提出从κ-阿片受体信号转导通路角度探讨针刺防治心肌顿抑的作用机制,为针刺改善心肌缺血性疾病的潜在机制提出新的研究思路。By reviewing the literature regarding the development mechanism of myocardial stunning, effects of acupuncture on myocardial ischemic injury, and correlation between acupuncture andκ-opioid receptor, it was suggested that acupuncture was highly likely to act on κ-opioid receptor in myocardial cells, and directly treated myocardial malfunction induced by myocardial stunning throughκ-opioid receptor and its signaling pathway. In addition, acupuncture could inhabit the signaling pathway of adrenoceptor β1, one of the main functional receptors, to indirectly improve myocardial ischemic injury. From κ-opioid receptor signaling pathway, the action mechanism of acupuncture for prevention and treatment of myocardial stunning was discussed in this paper, hoping to provide new ideas for possible mechanism of acupuncture for myocardial ischemic injury.

关 键 词：心肌顿抑 针刺 Κ-阿片受体 

分 类 号：R245[医药卫生—针灸推拿学]