老年2型糖尿病伴脑梗死患者血液流变学及凝血功能指标检测及意义  

Detection and significance of blood rheology and coagulation function in elderly patients with type 2 diabetes mellitus complicated with cerebral infarction

作　　者：刘明全[1] 杨敏[1] 黄飞 袁雪[1] 范静 

机构地区：[1]成都医学院第一附属医院检验科,四川成都610500

出　　处：《海南医学院学报》2018年第1期125-128,共4页Journal of Hainan Medical University

基　　金：四川省成都市科技局资助基金(VC27912)~~

摘　　要：目的:探讨老年2型糖尿病(T2DM)伴脑梗死患者血液流变学及凝血功能指标水平及意义。方法:选择81例老年T2DM伴脑梗死患者设为观察组,T2DM无脑梗死患者80例作为T2DM组,另选取健康体检老年人80例作为对照组;观察组患者依据Adama分型又可分为腔隙性脑梗死组(n=28)、小梗死组(n=39)和大梗死组(n=14)三组,比较各组间血液流变学及凝血功能指标水平。结果:单因素方差分析结果表明,对照组、T2DM组和观察组间高切全血黏度、低切全血黏度、血浆黏度、APTT、PT、FIB及D-D水平差异均具有统计学意义(P<0.05);与对照组相比,T2DM组和观察组高切全血黏度、低切全血黏度、血浆黏度、FIB及D-D水平均显著升高,APTT、PT水平显著降低(P<0.05),且观察组高切全血黏度、低切全血黏度、血浆黏度、FIB及D-D水平显著高于T2DM组,APTT、PT水平显著低于T2DM组,差异有统计学意义(P<0.05);与腔隙性脑梗死组相比,小梗死组与大梗死组随着梗死面积的增加,患者高切全血黏度、低切全血黏度、血浆黏度、FIB及D-D水平依次显著升高,而APTT、PT水平显著降低,组间差异具有统计学意义(P<0.05)。结论:T2DM伴脑梗死患者血液流变学指标及凝血功能异常,其指标检测对脑梗死面积评估具有重要临床价值。Objective:To investigate the level of blood rheology and coagulation function in elderly patients with type 2 diabetes mellitus(T2 DM)and cerebral infarction and its significance.Methods:81 elderly patients with T2 DM and cerebral infarction were selected as the observation group,80 cases of T2 DM group without cerebral infarction were selected as T2 DM group,and 80 healthy elderly people as control group.According to the Adama classification,the patients in the observation group were divided into three groups:lacunar infarction group(n=28),small infarction group(n=39)and large infarction group(n=14).The blood rheology and coagulation function indexes levels among the groups were compared.Results:The single factor variance analysis showed that the differences of the high shear whole blood viscosity,plasma viscosity,low shear whole blood viscosity,APTT,PT,FIB and D-D levels among the control group,T2 DM group and observation group were statistically significant(P<0.05).Compared with the control group levels,the high blood viscosity,plasma viscosity,low shear whole blood viscosity,FIB and D-D levels in the T2 DM group and observation group were significantly increased,PT and APTT were decreased sharply(P<0.05),and the observation group high blood viscosity,plasma viscosity,low shear whole blood viscosity,FIB and D-D levels were significantly higher than that of T2 DM group APTT,and PT were significantly lower than those of T2 DM group(P<0.05).Lacunar infarction group,small infarction group and large infarction group with increased infarct size,with high shear whole blood viscosity,plasma viscosity,low shear whole blood viscosity,FIB and D-D levels were significantly increased,while APTT and PT were significantly decreased(P<0.05).Conclusion:T2 DM and cerebral infarction patients with abnormal blood rheology and coagulation function,the index examination has important clinical value for cerebral infarction area evaluation.

关 键 词：2型糖尿病 脑梗死 血液流变学 凝血功能 检测价值 

分 类 号：R587.1[医药卫生—内分泌]