血小板血型抗体与分娩次数及早期流产的相关性分析  

Correlation analysis between platelet-specific alloantibody and delivery times or early abortion

作　　者：叶水文[1] 张楠[1] 饶美英[1] 

机构地区：[1]南昌大学第二附属医院,江西南昌330006

出　　处：《实验与检验医学》2017年第6期833-835,共3页Experimental and Laboratory Medicine

基　　金：江西省卫计委课题;编号:20175241

摘　　要：目的探讨血小板血型抗体与分娩次数及早期流产的关系。方法选择2016年4月-2016年12月在南昌大学第二附属医院产科进行产前检查的孕龄为36~40周的初产妇142例(分娩次数=0)、经产妇244例(既往分娩次数≥1)、无早期流产史120例、有早期流产史的246例(早期流产次数≥1)为研究对象。利用固相凝集法检测各组血清中血小板抗体。结果初产妇组、经产妇组测出血小板血型抗体阳性8例(5.6%)、30例(12.3%),两组比较差异有统计学意义(P<0.05)。无早期流产组、有早期流产组血小板血型抗体阳性分别为8例(6.8%)和28例(11.4%),两组比较差异亦有统计学意义(P<0.05)。结论血小板血型抗体的产生与分娩次数及早期流产史密切相关,其筛查有利于早期流产及新生儿同种免疫性血小板减少性紫癜的预防和流产病因分析。Objective To study the relationship between platelet-specific alloantibody and delivery times or early abortion.Methods A total of 142 primipara(Past delivery times=0),244 pluripara(Past deliver times≥1),120 without and 246 with early abortion history women were selected from the Second Affiliated Hospital of Nanchang University from May 2016 to December2016. The expression of platelet-specific alloantibody was detected by solid state agglutination assay. Results There were 8 positive platelet-specific alloantibody in primipara group and 30 in pluripara group(5.6% vs 12.3%,P<0.05),respectively. Eight positive in the women without early abortion history and 28 in the women who had early abortion history(6.8% vs 11.4%,P <0.05).Conclusion Platelet-specific alloantibody was significantly associated with delivery times and early abortiont. It is helpful to analysis of the cause of abortion and the prevention of neonatal autoimmune thrombocytoponia purpura by the method of solid state agglutination method.

关 键 词：血小板血型抗体 固相凝集法 既往分娩史 早期流产 

分 类 号：R714.21[医药卫生—妇产科学]