肾功能对血清ProGRP的影响分析  

Analysis of the renal function's influence on serum ProGRP

作　　者：何华[1] 胡蓉[1] 黄俊云[1] 钟田雨[1] 汤显湖[2] 陈晓红[1] 吴相圣 江丽霞[1] 

机构地区：[1]赣南医学院第一附属医院检验科,江西赣州341000 [2]赣南医学院第一附属医院肾内科,江西赣州341000

出　　处：《实验与检验医学》2017年第6期845-846,853,共3页Experimental and Laboratory Medicine

基　　金：江西省卫生计生委科技计划项目(No.20165371);赣州市指导性科技计划项目(No.GZ2015ZSF012)

摘　　要：目的探讨肾功能对血清胃泌素释放肽前体(Pro GRP)水平的影响。方法以2015年1月至2016年12月赣南医学院第一附属医院肾内科收治的146例非肿瘤性肾功能损害患者为研究对象,检测其血清胃泌素释放肽前体(Pro GRP)、神经元特异性烯醇化酶(NSE)、尿素(Urea)、肌酐(CRE)、胱抑素C(Cys C)等指标。先采用Cockcroft-Gault公式估算研究对象内生肌酐清除率(Ccr),然后再根据Ccr将他们分为5组:Ccr>80ml/min为A组(29例)、Ccr 51~80ml/min为B组(27例)、Ccr 20~50ml/min为C组(28例)、Ccr 10~19ml/min为D组(32例)、Ccr<10ml/min为E组(30例)。结果⑴不同Ccr组之间患者血清Pro GRP水平比较差异有统计学意义(F=17.476,P<0.01),两两比较显示E组血清Pro GRP水平显著高于A组、B组、C组、D组(P<0.05),D组血清Pro GRP水平显著高于A组、B组、C组(P<0.05),A组、B组、C组之间血清Pro GRP水平两两比较差异无统计学意义(P>0.05)。⑵研究对象血清Pro GRP与血清Urea(r=0.395,P<0.01)、CRE(r=0.510,P<0.01)、Cys C(r=0.575,P<0.01)呈显著正相关,与Ccr(r=-0.558,P<0.01)呈显著负相关。血清NSE与血清Urea(r=0.108,P>0.05)、CRE(r=0.068,P>0.05)、Cys C(r=0.067,P>0.05)、Ccr(r=0.010,P>0.05)无显著相关性。结论肾功能受损对血清Pro GRP水平存在影响,用Pro GRP辅助诊断小细胞肺癌(SCLC)时应排除肾功能损害的影响。Objective To investigate the effect of renal function on the level of serum gastrin-releasing peptide precursor(Pro GRP). Methods 146 patients with non-neoplastic renal dysfunction were enrolled in this study from January 2015 to December 2016 in Nephrology department of the First Affiliated Hospital of Gannan Medical College,we obtained some data of serum pro-gastrin-releasing peptide(Pro GRP),Neuron specific enolase(NSE),Urea(Urea),Creatinine(CRE) and Cystatin C(Cys C),etc.which are computed by using the Cockcroft-Gault formula to estimate the Creatinine clearance rate(Ccr). Results ⑴There was significant difference in serum Pro GRP levels among different Ccr groups(F=17.476,P<0.01). The level of Pro GRP in group E was significantly higher than that in group A,B,C and D(P<0.05),and the level of Pro GRP in group D was significantly higher than that in group A,B and C(P<0.05),the serum level of Pro GRP in group A,group B and group C has no significant difference between any two groups(P>0.05). ⑵The serum levels of Pro GRP was positively correlated with serum Urea(r=0.395,P<0.01),CRE(r=0.510,P<0.01) and Cys C(r=0.575,P<0.01). Serum NSE had no significant correlation with serum Urea(r=0.108,P>0.05),CRE(r=0.068,P>0.05),Cys C(r=0.067,P>0.05). Conclusion Impaired renal function has an impact on serum Pro GRP level and Pro GRP could contribute to diagnose small cell lung cancer(SCLC).

关 键 词：胃泌素释放肽前体 肾功能 小细胞肺癌 

分 类 号：R446.112[医药卫生—诊断学]