头孢呋辛与左氧氟沙星治疗泌尿系统感染疗效观察及对炎症因子的影响  

Effect of cefuroxime combined with levofloxacin on treatment of urinary tract infections and influence on inflammatory factors

作　　者：曹译丹[1] 刘鑫[1] 王晓庆[2] 闫荟羽[3] 陶娌娜[4] 李雪松[1] 

机构地区：[1]吉林大学第一医院药学部急诊药房,吉林长春130021 [2]吉林大学第一医院泌尿科,吉林长春130021 [3]吉林大学第一医院药学部临床药学,吉林长春130021 [4]吉林大学第一医院药学部实验室,吉林长春130021

出　　处：《中华医院感染学杂志》2018年第1期44-46,共3页Chinese Journal of Nosocomiology

摘　　要：目的观察应用头孢呋辛与左氧氟沙星治疗泌尿系统感染患者的临床综合疗效。方法选取2015年12月-2016年12月期间医院泌尿科收治的住院患者288例作为研究对象,对其泌尿系统感染情况进行统计,针对泌尿系统感染患者给予头孢呋辛与左氧氟沙星联合治疗,观察患者治疗的综合疗效,比较治疗前后血清和尿液白介素(IL)和组织因子(TF)指标水平。结果 288例患者共发生泌尿系统感染56例,感染率为19.44%;56例感染患者经治疗后,治愈患者38例,显效患者10例,有效患者7例,无效患者1例,治疗总有效率为98.21%;全部患者均未见不良反应;感染患者治疗后血清和尿液的IL-4、IL-6、IL-8、IL-12和TF等指标水平均明显降低(P<0.05)。结论头孢呋辛与左氧氟沙星联合治疗泌尿系统感染临床疗效显著,治疗后患者血清和尿液白介素、组织因子水平得到显著改善。OBJECTIVE To observe the clinical effect of cefuroxime combined with levofloxacin on treatment of pa- tients with urinary tract infections.METHODS A total of 288 patients who were hospitalized the urology depart- ment from Dec 2015 to Dec 2016 were recruited as the study objects, the prevalence of urinary tract infections was statistically analyzed, the patients with urinary tract infections were treated with cefuroxime combined with levo- floxacin, the comprehensive therapeutic effect was observed, and the levels of serum and urine interleukins （IL） and tissue factors（TF） were compared before and after the treatment.RESULTS Of the 288 patients, 56 had urina- ry tract infections, with the infection rate 19.44~.Among the 56 patients with infection, 38 were cured after the treatment, 10 were improved, 7 were effective, 1 was ineffective, and the total effective rate of treatment was 98.21%.All of the patients did not have adverse reactions.The levels of serum and urine IL-4, IL-6, IL-8, IL-12 and TF of the patients with infection were significantly reduced after the treatment （P〈0.05）.CONCLUSION Ce- furoxime combined with levofloxacin can achieve remarkable clinical effect on treatment of the patients with urina- ry tract infections. The levels of serum and urine interleukins and levels of inflammatory factors are significantly improved.

关 键 词：头孢呋辛 左氧氟沙星 泌尿系统感染 白介素 组织因子 

分 类 号：R693.1[医药卫生—泌尿科学]