单取代/双取代氧化吲哚衍生物的合成研究  

Synthesis of Oxindole Derivatives with Monosubstituted and Disubstituted

作　　者：周鑫鑫[1] 周宁[1] 刘长春[1] 

机构地区：[1]江苏食品药品职业技术学院药学院

出　　处：《化学试剂》2018年第1期97-102,共6页Chemical Reagents

摘　　要：氧化吲哚是药物分子和天然产物中较为常见的杂环化合物,具有很高的应用价值。采用不同的衍生方法能合成不同结构的衍生物,可制备高生物活性药物。以吲哚、靛红为原料,采用Lewis酸作催化剂,采用不同的反应条件选择性地合成了13个单取代氧化吲哚衍生物和13个双取代氧化吲哚衍生物,反应产率为77%～98%,其结构经^1HNMR表征。Oxoindole is a common heterocyclic compound in drug molecules and natural products,and has high application value.Different structure derivatives can be synthesized by using different procedure,which can provide highly bioactive drugs.Monosubstituted and disubstituted oxindole derivatives were synthesized separately from isatins and indoles in good to excellent yields by using different Lewis acid catalysts with the yield of 77% ～ 98%.The structures were confirmed by ^1HNMR.

关 键 词：吲哚 靛红 Lewis酸催化剂 氧化吲哚衍生物 

分 类 号：O626[理学—有机化学]