3种丹皮酚凝胶经皮渗透性能的比较  

Comparison of three paeonol gels in their percutaneous penetration performance

作　　者：蔡雅琴[1] 冯军[1] 侯延辉[1,2] 王文苹[1,2,3] 

机构地区：[1]宁夏医科大学药学院,宁夏银川750004 [2]宁夏医科大学,宁夏回药现代化工程技术研究中心,宁夏银川750004 [3]宁夏医科大学,回医药现代化省部共建教育部重点实验室,宁夏银川750004

出　　处：《中成药》2018年第1期66-70,共5页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金资助项目(81760713)

摘　　要：目的比较3种丹皮酚凝胶经皮渗透性能。方法 Franz扩散池法考察低共熔纳米乳凝胶、普通纳米乳凝胶、饱和溶液凝胶在离体小鼠皮肤上的渗透及滞留行为,胶带剥离法比较志愿者涂抹凝胶后在角质层和毛囊中的滞留量和渗透量。结果各凝胶在离体小鼠皮肤上的累积渗透量和滞留量均依次为低共熔纳米乳凝胶>普通纳米乳凝胶>饱和溶液凝胶。3种凝胶均主要滞留在志愿者皮肤表面,而且低共熔、普通纳米乳凝胶的透过量及在角质层和毛囊中的滞留量明显高于饱和溶液凝胶(P<0.05)。结论纳米乳技术可显著促进丹皮酚经皮渗透性能。AIM To compare the percutaneous penetration performance of three paeonol gels. METHODS Franz diffusion cell method was applied to investigating the penetration and retention behaviors of eutectic mixture- based nanoemulsion, ordinary nanoemulsion and saturated solution gels onto mouse skins in vitro. The retention and permeation amounts in stratum corneum and hair follicles of volunteers smeared with gels were compared by tape stripping method. RESULTS The accumulative permeation and retention amounts of various gels onto mouse skins in vitro were in sequence of euteetie mixture-based nanoemulsion gel 〉 ordinary nanoemulsion gel 〉 saturated solution gel. The main retention of all the three gels was observed on the volunteers＇ skin surface, and the perme- ation amounts of eutectic mixture-based nanoemulsion, ordinary nanoemulsion gels, and their accumulative perme- ation amounts in stratum corneum and hair follicles were significantly higher than those of saturated solution gel （P 〈 0. 05 ）. CONCLUSION Nanoemulsion technology can significantly promote the percutaneous penetration performance of paeonol.

关 键 词：丹皮酚 凝胶 经皮渗透 Franz扩散池法 胶带剥离法 

分 类 号：R969.1[医药卫生—药理学]